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Sorting nexin 9
Protein SNX9 PDB 2RAI.png
Rendering based on PDB 2RAI.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols SNX9 ; SDP1; SH3PX1; SH3PXD3A; WISP
External IDs OMIM605952 MGI1913866 HomoloGene49454 GeneCards: SNX9 Gene
RNA expression pattern
PBB GE SNX9 gnf1h00218 at tn.png
More reference expression data
Species Human Mouse
Entrez 51429 66616
Ensembl ENSG00000130340 ENSMUSG00000002365
UniProt Q9Y5X1 Q91VH2
RefSeq (mRNA) NM_016224 NM_025664
RefSeq (protein) NP_057308 NP_079940
Location (UCSC) Chr 6:
157.7 – 157.95 Mb
Chr 17:
5.84 – 5.93 Mb
PubMed search [1] [2]

Sorting nexin-9 is a protein that in humans is encoded by the SNX9 gene.[1][2][3]

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but does contain an SH3 domain near its N-terminus. This protein interacts with the cytoplasmic domains of the precursor but not the processed forms of a disintegrin and metalloprotease domain 9 and 15. This protein binds the beta-appendage domain of adaptor protein 2 and may function to assist adaptor protein 2 in its role at the plasma membrane. This protein interacts with activated Cdc42-associated kinase-2 to regulate the degradation of epidermal growth factor receptor protein.[3]


SNX9 has been shown to interact with ADAM9,[1] DNM2[4] and ADAM15.[1]


  1. ^ a b c Howard L, Nelson KK, Maciewicz RA, Blobel CP (Dec 1999). "Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1". J Biol Chem 274 (44): 31693–9. doi:10.1074/jbc.274.44.31693. PMID 10531379. 
  2. ^ Yarar D, Waterman-Storer CM, Schmid SL (Jul 2007). "SNX9 couples actin assembly to phosphoinositide signals and is required for membrane remodeling during endocytosis". Dev Cell 13 (1): 43–56. doi:10.1016/j.devcel.2007.04.014. PMID 17609109. 
  3. ^ a b "Entrez Gene: SNX9 sorting nexin 9". 
  4. ^ Lundmark, Richard; Carlsson Sven R (Nov 2003). "Sorting nexin 9 participates in clathrin-mediated endocytosis through interactions with the core components". J. Biol. Chem. (United States) 278 (47): 46772–81. doi:10.1074/jbc.M307334200. ISSN 0021-9258. PMID 12952949. 

Further reading[edit]