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Suppressor of cytokine signaling 2
Protein SOCS2 PDB 2c9w.png
PDB rendering based on 2c9w.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols SOCS2 ; CIS2; Cish2; SOCS-2; SSI-2; SSI2; STATI2
External IDs OMIM605117 MGI1201787 HomoloGene2880 GeneCards: SOCS2 Gene
RNA expression pattern
PBB GE SOCS2 203373 at tn.png
PBB GE SOCS2 203372 s at tn.png
More reference expression data
Species Human Mouse
Entrez 8835 216233
Ensembl ENSG00000120833 ENSMUSG00000020027
UniProt O14508 O35717
RefSeq (mRNA) NM_001270467 NM_001168655
RefSeq (protein) NP_001257396 NP_001162126
Location (UCSC) Chr 12:
93.57 – 93.58 Mb
Chr 10:
95.39 – 95.42 Mb
PubMed search [1] [2]

Suppressor of cytokine signaling 2 is a protein that in humans is encoded by the SOCS2 gene.[1][2][3]

This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signalling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10 and interferon-gamma (IFN-gamma). The protein encoded by this gene is found to interact with the cytoplasmic domain of insulin-like growth factor 1 receptor (IGF1R), and thus is thought to be involved in the regulation of IGF1R mediated cell signaling.[4] Knockout studies in mice also suggested a regulatory role of this gene in IGF-1 related growth control.[3][5]


SOCS2 has been shown to interact with Insulin-like growth factor 1 receptor[4] and Erythropoietin receptor.[6]


  1. ^ Masuhara M, Sakamoto H, Matsumoto A, Suzuki R, Yasukawa H, Mitsui K, Wakioka T, Tanimura S, Sasaki A, Misawa H, Yokouchi M, Ohtsubo M, Yoshimura A (November 1997). "Cloning and characterization of novel CIS family genes". Biochem Biophys Res Commun 239 (2): 439–46. doi:10.1006/bbrc.1997.7484. PMID 9344848. 
  2. ^ Minamoto S, Ikegame K, Ueno K, Narazaki M, Naka T, Yamamoto H, Matsumoto T, Saito H, Hosoe S, Kishimoto T (September 1997). "Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3". Biochem Biophys Res Commun 237 (1): 79–83. doi:10.1006/bbrc.1997.7080. PMID 9266833. 
  3. ^ a b "Entrez Gene: SOCS2 suppressor of cytokine signaling 2". 
  4. ^ a b Dey BR, Spence SL, Nissley P, Furlanetto RW (September 1998). "Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor". J. Biol. Chem. 273 (37): 24095–101. doi:10.1074/jbc.273.37.24095. PMID 9727029. 
  5. ^ Greenhalgh CJ, Bertolino P, Asa SL, Metcalf D, Corbin JE, Adams TE, Davey HW, Nicola NA, Hilton DJ, Alexander WS (June 2002). "Growth enhancement in suppressor of cytokine signaling 2 (SOCS-2)-deficient mice is dependent on signal transducer and activator of transcription 5b (STAT5b)". Mol. Endocrinol. 16 (6): 1394–406. doi:10.1210/me.16.6.1394. PMID 12040024. 
  6. ^ Eyckerman, S; Verhee A; der Heyden J V; Lemmens I; Ostade X V; Vandekerckhove J; Tavernier J (Dec 2001). "Design and application of a cytokine-receptor-based interaction trap". Nat. Cell Biol. (England) 3 (12): 1114–9. doi:10.1038/ncb1201-1114. ISSN 1465-7392. PMID 11781573. 

Further reading[edit]

  • Lopaczynski W (1999). "Differential regulation of signaling pathways for insulin and insulin-like growth factor I.". Acta Biochim. Pol. 46 (1): 51–60. PMID 10453981. 
  • Wang J, Campbell IL (2002). "Cytokine signaling in the brain: putting a SOCS in it?". J. Neurosci. Res. 67 (4): 423–7. doi:10.1002/jnr.10145. PMID 11835308. 
  • Kile BT, Schulman BA, Alexander WS, et al. (2002). "The SOCS box: a tale of destruction and degradation.". Trends Biochem. Sci. 27 (5): 235–41. doi:10.1016/S0968-0004(02)02085-6. PMID 12076535. 
  • Pezet A, Buteau H, Kelly PA, Edery M (1997). "The last proline of Box 1 is essential for association with JAK2 and functional activation of the prolactin receptor.". Mol. Cell. Endocrinol. 129 (2): 199–208. doi:10.1016/S0303-7207(97)00063-4. PMID 9202403. 
  • Dey BR, Spence SL, Nissley P, Furlanetto RW (1998). "Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor.". J. Biol. Chem. 273 (37): 24095–101. doi:10.1074/jbc.273.37.24095. PMID 9727029. 
  • Pezet A, Favre H, Kelly PA, Edery M (1999). "Inhibition and restoration of prolactin signal transduction by suppressors of cytokine signaling.". J. Biol. Chem. 274 (35): 24497–502. doi:10.1074/jbc.274.35.24497. PMID 10455112. 
  • Yandava CN, Pillari A, Drazen JM (1999). "Radiation hybrid and cytogenetic mapping of SOCS1 and SOCS2 to chromosomes 16p13 and 12q, respectively.". Genomics 61 (1): 108–11. doi:10.1006/geno.1999.5937. PMID 10512686. 
  • Ram PA, Waxman DJ (2000). "SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms.". J. Biol. Chem. 274 (50): 35553–61. doi:10.1074/jbc.274.50.35553. PMID 10585430. 
  • Metcalf D, Greenhalgh CJ, Viney E, et al. (2000). "Gigantism in mice lacking suppressor of cytokine signalling-2.". Nature 405 (6790): 1069–73. doi:10.1038/35016611. PMID 10890450. 
  • Shen X, Hong F, Nguyen VA, Gao B (2000). "IL-10 attenuates IFN-alpha-activated STAT1 in the liver: involvement of SOCS2 and SOCS3.". FEBS Lett. 480 (2-3): 132–6. doi:10.1016/S0014-5793(00)01905-0. PMID 11034314. 
  • Eyckerman S, Verhee A, der Heyden JV, et al. (2002). "Design and application of a cytokine-receptor-based interaction trap.". Nat. Cell Biol. 3 (12): 1114–9. doi:10.1038/ncb1201-1114. PMID 11781573. 
  • Schultheis B, Carapeti-Marootian M, Hochhaus A, et al. (2002). "Overexpression of SOCS-2 in advanced stages of chronic myeloid leukemia: possible inadequacy of a negative feedback mechanism.". Blood 99 (5): 1766–75. doi:10.1182/blood.V99.5.1766. PMID 11861294. 
  • Blumenstein M, Bowen-Shauver JM, Keelan JA, Mitchell MD (2002). "Identification of suppressors of cytokine signaling (SOCS) proteins in human gestational tissues: differential regulation is associated with the onset of labor.". J. Clin. Endocrinol. Metab. 87 (3): 1094–7. doi:10.1210/jc.87.3.1094. PMID 11889171. 
  • Biener E, Maurice S, Sandowski Y, et al. (2003). "Recombinant human CIS2 (SOCS2) protein: subcloning, expression, purification, and characterization.". Protein Expr. Purif. 25 (2): 305–12. doi:10.1016/S1046-5928(02)00013-X. PMID 12135564. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 

External links[edit]