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Suppressor of cytokine signaling 5
Symbols SOCS5 ; CIS6; CISH6; Cish5; SOCS-5
External IDs OMIM607094 MGI2385459 HomoloGene10495 GeneCards: SOCS5 Gene
Species Human Mouse
Entrez 9655 56468
Ensembl ENSG00000171150 ENSMUSG00000037104
UniProt O75159 O54928
RefSeq (mRNA) NM_014011 NM_019654
RefSeq (protein) NP_054730 NP_062628
Location (UCSC) Chr 2:
46.7 – 46.76 Mb
Chr 17:
87.11 – 87.14 Mb
PubMed search [1] [2]

Suppressor of cytokine signaling 5 is a protein that in humans is encoded by the SOCS5 gene.[1][2][3]

The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS) family, also known as STAT-induced STAT inhibitor (SSI) protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The specific function of this protein has not yet been determined. Two alternatively spliced transcript variants encoding an identical protein have been reported.[3]


  1. ^ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811. 
  2. ^ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166. 
  3. ^ a b "Entrez Gene: SOCS5 suppressor of cytokine signaling 5". 

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