SOCS5

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SOCS5
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases SOCS5, CIS6, CISH6, Cish5, SOCS-5, suppressor of cytokine signaling 5
External IDs MGI: 2385459 HomoloGene: 10495 GeneCards: SOCS5
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_144949
NM_014011

NM_019654

RefSeq (protein)

NP_054730
NP_659198

NP_062628.2
NP_062628

Location (UCSC) Chr 2: 46.7 – 46.76 Mb Chr 17: 87.11 – 87.14 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Suppressor of cytokine signaling 5 is a protein that in humans is encoded by the SOCS5 gene.[3][4][5]

The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS) family, also known as STAT-induced STAT inhibitor (SSI) protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The specific function of this protein has not yet been determined. Two alternatively spliced transcript variants encoding an identical protein have been reported.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811. 
  4. ^ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072Freely accessible. PMID 11230166. 
  5. ^ a b "Entrez Gene: SOCS5 suppressor of cytokine signaling 5". 

Further reading[edit]