Suppressor of cytokine signaling 6 is a protein that in humans is encoded by the SOCS6gene.
The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines.
^Masuhara M, Sakamoto H, Matsumoto A, Suzuki R, Yasukawa H, Mitsui K, Wakioka T, Tanimura S, Sasaki A, Misawa H, Yokouchi M, Ohtsubo M, Yoshimura A (Nov 1997). "Cloning and characterization of novel CIS family genes". Biochem Biophys Res Commun239 (2): 439–46. doi:10.1006/bbrc.1997.7484. PMID9344848.
Mooney RA, Senn J, Cameron S, et al. (2001). "Suppressors of cytokine signaling-1 and -6 associate with and inhibit the insulin receptor. A potential mechanism for cytokine-mediated insulin resistance.". J. Biol. Chem.276 (28): 25889–93. doi:10.1074/jbc.M010579200. PMID11342531.
Bayle J, Letard S, Frank R, et al. (2004). "Suppressor of cytokine signaling 6 associates with KIT and regulates KIT receptor signaling.". J. Biol. Chem.279 (13): 12249–59. doi:10.1074/jbc.M313381200. PMID14707129.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells.". Science307 (5715): 1621–5. doi:10.1126/science.1105776. PMID15761153.
Bayle J, Lopez S, Iwaï K, et al. (2006). "The E3 ubiquitin ligase HOIL-1 induces the polyubiquitination and degradation of SOCS6 associated proteins.". FEBS Lett.580 (11): 2609–14. doi:10.1016/j.febslet.2006.03.093. PMID16643902.
Hwang MN, Ha TH, Park J, et al. (2007). "Increased SOCS6 stability with PMA requires its N-terminal region and the Erk pathway via Pkcdelta activation.". Biochem. Biophys. Res. Commun.354 (1): 184–9. doi:10.1016/j.bbrc.2006.12.175. PMID17210122.
Hwang MN, Min CH, Kim HS, et al. (2007). "The nuclear localization of SOCS6 requires the N-terminal region and negatively regulates Stat3 protein levels.". Biochem. Biophys. Res. Commun.360 (2): 333–8. doi:10.1016/j.bbrc.2007.06.062. PMID17603019.