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Available structures
PDB Ortholog search: PDBe RCSB
Aliases SOCS6, CIS-4, CIS4, HSPC060, SOCS-4, SOCS-6, SOCS4, SSI4, STAI4, STATI4, suppressor of cytokine signaling 6
External IDs MGI: 1924885 HomoloGene: 3120 GeneCards: SOCS6
Gene location (Human)
Chromosome 18 (human)
Chr. Chromosome 18 (human)[1]
Chromosome 18 (human)
Genomic location for SOCS6
Genomic location for SOCS6
Band No data available Start 70,288,901 bp[1]
End 70,330,200 bp[1]
RNA expression pattern
PBB GE SOCS6 206020 at fs.png

PBB GE SOCS6 214462 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 18: 70.29 – 70.33 Mb Chr 18: 88.67 – 88.93 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Suppressor of cytokine signaling 6 is a protein that in humans is encoded by the SOCS6 gene.[5][6][7]

The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI) protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines.[7]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000170677 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000056153 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Masuhara M, Sakamoto H, Matsumoto A, Suzuki R, Yasukawa H, Mitsui K, Wakioka T, Tanimura S, Sasaki A, Misawa H, Yokouchi M, Ohtsubo M, Yoshimura A (Nov 1997). "Cloning and characterization of novel CIS family genes". Biochem Biophys Res Commun. 239 (2): 439–46. PMID 9344848. doi:10.1006/bbrc.1997.7484. 
  6. ^ Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. PMC 310934Freely accessible. PMID 11042152. doi:10.1101/gr.140200. 
  7. ^ a b "Entrez Gene: SOCS6 suppressor of cytokine signaling 6". 

Further reading[edit]