SOCS7

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SOCS7
Identifiers
Aliases SOCS7, NAP4, NCKAP4, suppressor of cytokine signaling 7
External IDs MGI: 2651588 HomoloGene: 16331 GeneCards: SOCS7
RNA expression pattern
PBB GE SOCS7 214015 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014598

NM_138657

RefSeq (protein)

NP_055413

NP_619598.1
NP_619598

Location (UCSC) Chr 17: 38.35 – 38.41 Mb Chr 11: 97.36 – 97.4 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Suppressor of cytokine signaling 7 is a protein that in humans is encoded by the SOCS7 gene.[3][4][5]

Model organisms[edit]

Model organisms have been used in the study of SOCS7 function. A conditional knockout mouse line, called Socs7tm1a(EUCOMM)Wtsi[11][12] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[13][14][15]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[9][16] Twenty five tests were carried out on mutant mice and one significant abnormality was observed: homozygous mutant males showed a decreased response to stress-induced hyperthermia.[9]

Interactions[edit]

SOCS7 has been shown to interact with NCK1.[3]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b Matuoka K, Miki H, Takahashi K, Takenawa T (Oct 1997). "A novel ligand for an SH3 domain of the adaptor protein Nck bears an SH2 domain and nuclear signaling motifs". Biochemical and Biophysical Research Communications. 239 (2): 488–92. doi:10.1006/bbrc.1997.7492. PMID 9344857. 
  4. ^ Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ (May 2002). "The SOCS box: a tale of destruction and degradation". Trends in Biochemical Sciences. 27 (5): 235–41. doi:10.1016/S0968-0004(02)02085-6. PMID 12076535. 
  5. ^ "Entrez Gene: SOCS7 suppressor of cytokine signaling 7". 
  6. ^ "Body temperature data for Socs7". Wellcome Trust Sanger Institute. 
  7. ^ "Salmonella infection data for Socs7". Wellcome Trust Sanger Institute. 
  8. ^ "Citrobacter infection data for Socs7". Wellcome Trust Sanger Institute. 
  9. ^ a b c Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. 
  10. ^ Mouse Resources Portal, Wellcome Trust Sanger Institute.
  11. ^ "International Knockout Mouse Consortium". 
  12. ^ "Mouse Genome Informatics". 
  13. ^ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410Freely accessible. PMID 21677750. 
  14. ^ Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718. 
  15. ^ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. 
  16. ^ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biology. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837Freely accessible. PMID 21722353. 

Further reading[edit]