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Superoxide dismutase 3, extracellular
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols SOD3 ; EC-SOD
External IDs OMIM185490 MGI103181 HomoloGene2334 GeneCards: SOD3 Gene
EC number
RNA expression pattern
PBB GE SOD3 205236 x at tn.png
More reference expression data
Species Human Mouse
Entrez 6649 20657
Ensembl ENSG00000109610 ENSMUSG00000072941
UniProt P08294 O09164
RefSeq (mRNA) NM_003102 NM_011435
RefSeq (protein) NP_003093 NP_035565
Location (UCSC) Chr 4:
24.79 – 24.8 Mb
Chr 5:
52.36 – 52.37 Mb
PubMed search [1] [2]

Extracellular superoxide dismutase [Cu-Zn] is an enzyme that in humans is encoded by the SOD3 gene.

This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the dismutation of two superoxide radicals into hydrogen peroxide and oxygen. The product of this gene is thought to protect the brain, lungs, and other tissues from oxidative stress. The protein is secreted into the extracellular space and forms a glycosylated homotetramer that is anchored to the extracellular matrix (ECM) and cell surfaces through an interaction with heparan sulfate proteoglycan and collagen. A fraction of the protein is cleaved near the C-terminus before secretion to generate circulating tetramers that do not interact with the ECM.[1]


Further reading[edit]