SOD3

From Wikipedia, the free encyclopedia
Jump to: navigation, search
SOD3
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases SOD3, EC-SOD, superoxide dismutase 3, extracellular
External IDs MGI: 103181 HomoloGene: 2334 GeneCards: 6649
RNA expression pattern
PBB GE SOD3 205236 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003102

NM_011435

RefSeq (protein)

NP_003093.2

NP_035565.1

Location (UCSC) Chr 4: 24.79 – 24.8 Mb Chr 5: 52.36 – 52.37 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Extracellular superoxide dismutase [Cu-Zn] is an enzyme that in humans is encoded by the SOD3 gene.

This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the dismutation of two superoxide radicals into hydrogen peroxide and oxygen. The product of this gene is thought to protect the brain, lungs, and other tissues from oxidative stress. The protein is secreted into the extracellular space and forms a glycosylated homotetramer that is anchored to the extracellular matrix (ECM) and cell surfaces through an interaction with heparan sulfate proteoglycan and collagen. A fraction of the protein is cleaved near the C-terminus before secretion to generate circulating tetramers that do not interact with the ECM.[1]

References[edit]

Further reading[edit]