SOD3

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SOD3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSOD3, EC-SOD, superoxide dismutase 3, extracellular, superoxide dismutase 3
External IDsMGI: 103181 HomoloGene: 2334 GeneCards: SOD3
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for SOD3
Genomic location for SOD3
Band4p15.2Start24,789,912 bp[1]
End24,800,842 bp[1]
RNA expression pattern
PBB GE SOD3 205236 x at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003102

NM_011435

RefSeq (protein)

NP_003093

NP_035565

Location (UCSC)Chr 4: 24.79 – 24.8 MbChr 5: 52.36 – 52.37 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Extracellular superoxide dismutase [Cu-Zn] is an enzyme that in humans is encoded by the SOD3 gene.

This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the dismutation of two superoxide radicals into hydrogen peroxide and oxygen. The product of this gene is thought to protect the brain, lungs, and other tissues from oxidative stress. The protein is secreted into the extracellular space and forms a glycosylated homotetramer that is anchored to the extracellular matrix (ECM) and cell surfaces through an interaction with heparan sulfate proteoglycan and collagen. A fraction of the protein is cleaved near the C-terminus before secretion to generate circulating tetramers that do not interact with the ECM.[5]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000109610 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000072941 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ "Entrez Gene: SOD3 superoxide dismutase 3, extracellular".

Further reading[edit]