SOS box

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SOS box is the region in the promoter of various genes to which the LexA repressor binds to repress the transcription in the absence of DNA damage.


Phylogenetic Clade Sequence Reference
Alpha Proteobacteria GAAC(N)7GAAC
Deltaproteobacteria CTRHAMRYBYGTTCAGS [4]
Gram-positive Bacteria CGAACRNRYGTTYC [5][6]
Cyanobacteria RGTAC(N)3DGTWCB [7]

See Nucleic acid nomenclature for an explanation of non-GATC nucleotide letters

See also[edit]


  1. ^ Fernández de Henestrosa AR, Rivera E, Tapias A, Barbé J (June 1998). "Identification of the Rhodobacter sphaeroides SOS box". Mol. Microbiol. 28 (5): 991–1003. doi:10.1046/j.1365-2958.1998.00860.x. PMID 9663685. 
  2. ^ Tapias A, Barbé J (August 1999). "Regulation of divergent transcription from the uvrA-ssb promoters in Sinorhizobium meliloti". Mol. Gen. Genet. 262 (1): 121–30. doi:10.1007/s004380051066. PMID 10503543. 
  3. ^ Erill I, Escribano M, Campoy S, Barbé J (November 2003). "In silico analysis reveals substantial variability in the gene contents of the gamma proteobacteria LexA-regulon". Bioinformatics 19 (17): 2225–36. doi:10.1093/bioinformatics/btg303. PMID 14630651. 
  4. ^ Campoy S, Fontes M, Padmanabhan S, Cortés P, Llagostera M, Barbé J (August 2003). "LexA-independent DNA damage-mediated induction of gene expression in Myxococcus xanthus". Mol. Microbiol. 49 (3): 769–81. doi:10.1046/j.1365-2958.2003.03592.x. PMID 12864858. 
  5. ^ Winterling KW, Chafin D, Hayes JJ et al. (15 April 1998). "The Bacillus subtilis DinR Binding Site: Redefinition of the Consensus Sequence". J. Bacteriol. 180 (8): 2201–11. PMC 107149. PMID 9555905. 
  6. ^ Davis EO, Dullaghan EM, Rand L (June 2002). "Definition of the Mycobacterial SOS Box and Use To Identify LexA-Regulated Genes in Mycobacterium tuberculosis". J. Bacteriol. 184 (12): 3287–95. doi:10.1128/JB.184.12.3287-3295.2002. PMC 135081. PMID 12029045. 
  7. ^ Mazón G, Lucena JM, Campoy S, Fernández de Henestrosa AR, Candau P, Barbé J (February 2004). "LexA-binding sequences in Gram-positive and cyanobacteria are closely related". Mol. Genet. Genomics 271 (1): 40–9. doi:10.1007/s00438-003-0952-x. PMID 14652736.