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SRY (sex determining region Y)-box 1
Symbol SOX1
Entrez 6656
HUGO 11189
OMIM 602148
RefSeq NM_005986
UniProt O00570
Other data
Locus Chr. 13 q34

SOX1 (for Sex determining region Y-box 1) is a transcription factor in the Sox protein family. SOX1 expression is restricted to neuroectoderm in the tetrapod embryo.[1][2] SOX1 is involved in early central nervous system development, where it is functionally redundant with SOX3 and to a lesser degree SOX2, and maintenance of neural progenitor cell identity. SOX1 is expressed particularly in the ventral striatum, and Sox1-deficient mice have altered striatum development, leading e.g. to epilepsy.[1]

See also[edit]


  1. ^ a b Guth SI, Wegner M (October 2008). "Having it both ways: Sox protein function between conservation and innovation". Cell. Mol. Life Sci. 65 (19): 3000–18. doi:10.1007/s00018-008-8138-7. PMID 18516494. 
  2. ^ Nitta KR, Takahashi S, Haramoto Y, Fukuda M, Onuma Y, Asashima M (December 2006). "Expression of Sox1 during Xenopus early embryogenesis". Biochem. Biophys. Res. Commun. 351 (1): 287–93. doi:10.1016/j.bbrc.2006.10.040. PMID 17056008.