SOX12

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SOX12
Identifiers
AliasesSOX12, SOX22, SRY-box 12
External IDsMGI: 98360 HomoloGene: 5057 GeneCards: SOX12
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for SOX12
Genomic location for SOX12
Band20p13Start325,595 bp[1]
End330,224 bp[1]
RNA expression pattern
PBB GE SOX12 204432 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006943

NM_011438

RefSeq (protein)

NP_008874

NP_035568

Location (UCSC)Chr 20: 0.33 – 0.33 MbChr 2: 152.39 – 152.4 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

SOX12 is a protein that in humans is encoded by the SOX12 gene.[5][6] Sox12 belongs to the SoxC group of Sox family of transcription factors, together with Sox4 and Sox11. Sox12-null knockout mice appear normal, unlike Sox4 or Sox11 knockout mice. This probably comes from functional redundancy with Sox4 and Sox11.[7] Sox12 is a weaker activator than both Sox4 and Sox11 in mouse.[8]

Members of the SOX family of transcription factors are characterized by the presence of a DNA-binding high mobility group (HMG) domain, homologous to the HMG box of sex-determining region Y (SRY). Forming a subgroup of the HMG domain superfamily, SOX proteins have been implicated in cell fate decisions in a diverse range of developmental processes. SOX transcription factors have diverse tissue-specific expression patterns during early development and have been proposed to act as target-specific transcription factors and/or as chromatin structure regulatory elements. The protein encoded by this gene was identified as a SOX family member based on conserved domains and its expression in various tissues suggests a role in both differentiation and maintenance of several cell types.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000177732 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000051817 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Jay P, Sahly I, Goze C, Taviaux S, Poulat F, Couly G, Abitbol M, Berta P (Aug 1997). "SOX22 is a new member of the SOX gene family, mainly expressed in human nervous tissue". Hum Mol Genet. 6 (7): 1069–77. doi:10.1093/hmg/6.7.1069. PMID 9215677.
  6. ^ a b "Entrez Gene: SOX12 SRY (sex determining region Y)-box 12".
  7. ^ Hoser M, Potzner MR, Koch JM, Bösl MR, Wegner M, Sock E (August 2008). "Sox12 Deletion in the Mouse Reveals Nonreciprocal Redundancy with the Related Sox4 and Sox11 Transcription Factors". Mol. Cell. Biol. 28 (15): 4675–87. doi:10.1128/MCB.00338-08. PMC 2493363. PMID 18505825.
  8. ^ Dy P, Penzo-Méndez A, Wang H, Pedraza CE, Macklin WB, Lefebvre V (May 2008). "The three SoxC proteins—Sox4, Sox11 and Sox12—exhibit overlapping expression patterns and molecular properties". Nucleic Acids Res. 36 (9): 3101–17. doi:10.1093/nar/gkn162. PMC 2396431. PMID 18403418.

Further reading[edit]