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SRY (sex determining region Y)-box 13
Protein SOX13 PDB 1i11.png
PDB rendering based on 1i11.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols SOX13 ; ICA12; Sox-13
External IDs OMIM604748 MGI98361 HomoloGene4159 GeneCards: SOX13 Gene
Species Human Mouse
Entrez 9580 20668
Ensembl ENSG00000143842 ENSMUSG00000070643
UniProt Q9UN79 Q04891
RefSeq (mRNA) NM_005686 NM_011439
RefSeq (protein) NP_005677 NP_035569
Location (UCSC) Chr 1:
204.07 – 204.13 Mb
Chr 1:
133.38 – 133.42 Mb
PubMed search [1] [2]

Transcription factor SOX-13 is a protein that in humans is encoded by the SOX13 gene.[1][2]

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. It has also been determined to be a type-1 diabetes autoantigen, also known as islet cell antibody 12.[2]

In melanocytic cells SOX13 gene expression may be regulated by MITF.[3]

See also[edit]


  1. ^ Roose J, Korver W, de Boer R, Kuipers J, Hurenkamp J, Clevers H (May 1999). "The Sox-13 gene: structure, promoter characterization, and chromosomal localization". Genomics 57 (2): 301–5. doi:10.1006/geno.1999.5779. PMID 10198172. 
  2. ^ a b "Entrez Gene: SOX13 SRY (sex determining region Y)-box 13". 
  3. ^ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. 

Further reading[edit]

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.