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Aliases SOX21, SOX25, SRY-box 21
External IDs MGI: 2654070 HomoloGene: 5143 GeneCards: SOX21
RNA expression pattern
PBB GE SOX21 208468 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 13: 94.71 – 94.71 Mb Chr 14: 118.23 – 118.24 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Transcription factor SOX-21 is a protein that in humans is encoded by the SOX21 gene.[3][4] It is a member of the Sox gene family of transcription factors.


In the chick embryo, Sox21 promotes neuronal cellular differentiation by counteracting the activity of Sox1, Sox2, and Sox3, which maintain neural cells in an undifferentiated state.[5]

SOX21 knockout mice display hair loss beginning from postnatal day 11. New hair regrowth was initiated a few days later but was followed by renewed hair loss. Sox21 is also expressed in the hair shaft cuticle in humans and consequently variants of the Sox21 gene could be responsible for some hair loss conditions in humans.[6]

See also[edit]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Malas S, Duthie S, Deloukas P, Episkopou V (Sep 1999). "The isolation and high-resolution chromosomal mapping of human SOX14 and SOX21; two members of the SOX gene family related to SOX1, SOX2, and SOX3". Mammalian Genome. 10 (9): 934–7. doi:10.1007/s003359901118. PMID 10441749. 
  4. ^ "Entrez Gene: SOX21 SRY (sex determining region Y)-box 21". 
  5. ^ Sandberg M, Källström M, Muhr J (Aug 2005). "Sox21 promotes the progression of vertebrate neurogenesis". Nature Neuroscience. 8 (8): 995–1001. doi:10.1038/nn1493. PMID 15995704. 
  6. ^ Kiso M, Tanaka S, Saba R, Matsuda S, Shimizu A, Ohyama M, Okano HJ, Shiroishi T, Okano H, Saga Y (Jun 2009). "The disruption of Sox21-mediated hair shaft cuticle differentiation causes cyclic alopecia in mice". Proceedings of the National Academy of Sciences of the United States of America. 106 (23): 9292–7. doi:10.1073/pnas.0808324106. PMC 2695080Freely accessible. PMID 19470461. Lay summaryReuters UK. 

Further reading[edit]