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Available structures
PDBOrtholog search: PDBe RCSB
AliasesSOX4, EVI16, SRY-box 4
External IDsMGI: 98366 HomoloGene: 2338 GeneCards: SOX4
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for SOX4
Genomic location for SOX4
Band6p22.3Start21,592,768 bp[1]
End21,598,619 bp[1]
RNA expression pattern
PBB GE SOX4 201418 s at fs.png

PBB GE SOX4 201416 at fs.png

PBB GE SOX4 201417 at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 6: 21.59 – 21.6 MbChr 13: 28.95 – 28.95 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Transcription factor SOX-4 is a protein that in humans is encoded by the SOX4 gene.[5][6][7]


This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (syntenin). The protein may function in the apoptosis pathway leading to cell death as well as to tumorigenesis and may mediate downstream effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone development. The solution structure has been resolved for the HMG-box of a similar mouse protein.[7]

Sox4 is expressed in lymphocytes (B and T) and is required for B lymphocyte development.[8]


SOX4 has been shown to interact with SDCBP.[9]

See also[edit]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000124766 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000076431 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Farr CJ, Easty DJ, Ragoussis J, Collignon J, Lovell-Badge R, Goodfellow PN (January 1994). "Characterization and mapping of the human SOX4 gene". Mamm Genome. 4 (10): 577–84. doi:10.1007/BF00361388. PMID 8268656.
  6. ^ Critcher R, Stitson RN, Wade-Martins R, Easty DJ, Farr CJ (October 1998). "Assignment of Sox4 to mouse chromosome 13 bands A3-A5 by fluorescence in situ hybridization; refinement of the human SOX4 location to 6p22.3 and of SOX20 to chromosome 17p12.3". Cytogenet Cell Genet. 81 (3–4): 294–5. doi:10.1159/000015052. PMID 9730625.
  7. ^ a b "Entrez Gene: SOX4 SRY (sex determining region Y)-box 4".
  8. ^ Smith E, Sigvardsson M (2004). "The roles of transcription factors in B lymphocyte commitment, development, and transformation". J. Leukoc. Biol. 75 (6): 973–81. doi:10.1189/jlb.1103554. PMID 14982952.
  9. ^ Geijsen N, Uings IJ, Pals C, Armstrong J, McKinnon M, Raaijmakers JA, Lammers JW, Koenderman L, Coffer PJ (August 2001). "Cytokine-specific transcriptional regulation through an IL-5Ralpha interacting protein". Science. 293 (5532): 1136–8. doi:10.1126/science.1059157. PMID 11498591.

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.