From Wikipedia, the free encyclopedia
Jump to: navigation, search
SRY (sex determining region Y)-box 5
Protein SOX5 PDB 1i11.png
PDB rendering based on 1i11.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols SOX5 ; L-SOX5; L-SOX5B; L-SOX5F
External IDs OMIM604975 MGI98367 HomoloGene21378 GeneCards: SOX5 Gene
RNA expression pattern
PBB GE SOX5 207336 at tn.png
More reference expression data
Species Human Mouse
Entrez 6660 20678
Ensembl ENSG00000134532 ENSMUSG00000041540
UniProt P35711 P35710
RefSeq (mRNA) NM_001261414 NM_001113559
RefSeq (protein) NP_001248343 NP_001107031
Location (UCSC) Chr 12:
23.53 – 23.95 Mb
Chr 6:
143.83 – 144.78 Mb
PubMed search [1] [2]

Transcription factor SOX-5 is a protein that in humans is encoded by the SOX5 gene.[1][2]

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The encoded protein may play a role in chondrogenesis. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding distinct isoforms have been identified for this gene.[2]

See also[edit]


  1. ^ Wunderle VM, Critcher R, Ashworth A, Goodfellow PN (Jan 1997). "Cloning and characterization of SOX5, a new member of the human SOX gene family". Genomics 36 (2): 354–8. doi:10.1006/geno.1996.0474. PMID 8812465. 
  2. ^ a b "Entrez Gene: SOX5 SRY (sex determining region Y)-box 5". 

Further reading[edit]