SOX5

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SOX5
Protein SOX5 PDB 1i11.png
Identifiers
Aliases SOX5, L-L-SOX5B, L-SOX5F, LAMSHF, SRY-box 5
External IDs MGI: 98367 HomoloGene: 21378 GeneCards: 6660
Genetically Related Diseases
Disease Name References
Azoospermia
systemic scleroderma
RNA expression pattern
PBB GE SOX5 207336 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001261414
NM_001261415
NM_006940
NM_152989
NM_178010

NM_001113559
NM_001243163
NM_011444

RefSeq (protein)

NP_001248343.1
NP_001248344.1
NP_008871.3
NP_694534.1
NP_821078.1

NP_001230092.1

Location (UCSC) Chr 12: 23.53 – 23.95 Mb Chr 6: 143.83 – 144.78 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Transcription factor SOX-5 is a protein that in humans is encoded by the SOX5 gene.[1][2]

Function[edit]

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The encoded protein may play a role in chondrogenesis. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding distinct isoforms have been identified for this gene.[2]

See also[edit]

References[edit]

  1. ^ Wunderle VM, Critcher R, Ashworth A, Goodfellow PN (Sep 1996). "Cloning and characterization of SOX5, a new member of the human SOX gene family". Genomics 36 (2): 354–8. doi:10.1006/geno.1996.0474. PMID 8812465. 
  2. ^ a b "Entrez Gene: SOX5 SRY (sex determining region Y)-box 5". 

Further reading[edit]