SOX5

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SOX5
Protein SOX5 PDB 1i11.png
Identifiers
Aliases SOX5, L-L-SOX5B, L-SOX5F, LAMSHF, SRY-box 5
External IDs MGI: 98367 HomoloGene: 21378 GeneCards: SOX5
Genetically Related Diseases
azoospermia, systemic scleroderma[1]
RNA expression pattern
PBB GE SOX5 207336 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001113559
NM_001243163
NM_011444
NM_001347506

RefSeq (protein)

NP_001230092.1
NP_001107031
NP_001230092
NP_001334435
NP_035574

Location (UCSC) Chr 12: 23.53 – 23.95 Mb Chr 6: 143.83 – 144.78 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Transcription factor SOX-5 is a protein that in humans is encoded by the SOX5 gene.[4][5]

Function[edit]

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The encoded protein may play a role in chondrogenesis. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding distinct isoforms have been identified for this gene.[5]

See also[edit]

References[edit]

  1. ^ "Diseases that are genetically associated with SOX5 view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ Wunderle VM, Critcher R, Ashworth A, Goodfellow PN (Sep 1996). "Cloning and characterization of SOX5, a new member of the human SOX gene family". Genomics. 36 (2): 354–8. doi:10.1006/geno.1996.0474. PMID 8812465. 
  5. ^ a b "Entrez Gene: SOX5 SRY (sex determining region Y)-box 5". 

Further reading[edit]