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SRY (sex determining region Y)-box 6
PBB Protein SOX6 image.jpg
PDB rendering based on 1i11.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols SOX6 ; HSSOX6; SOXD
External IDs OMIM607257 MGI98368 HomoloGene22631 GeneCards: SOX6 Gene
Species Human Mouse
Entrez 55553 20679
Ensembl ENSG00000110693 ENSMUSG00000051910
UniProt P35712 P40645
RefSeq (mRNA) NM_001145811 NM_001025559
RefSeq (protein) NP_001139283 NP_001020730
Location (UCSC) Chr 11:
15.97 – 16.74 Mb
Chr 7:
115.47 – 116.04 Mb
PubMed search [1] [2]

Transcription factor SOX-6 is a protein that in humans is encoded by the SOX6 gene.[1][2]

The SOX gene family encodes a group of transcription factors defined by the conserved high mobility group (HMG) DNA-binding domain. Unlike most transcription factors, SOX transcription factors bind to the minor groove of DNA, causing a 70- to 85-degree bend and introducing local conformational changes.[supplied by OMIM][2]


SOX6 has been shown to interact with CTBP2[3] and CENPK.[4]

It has also been demonstrated that SOX6 protein accumulates in the differentiating human erythrocytes, and then is able to downregulate its own transcription, by directly binding to an evolutionarily conserved consensus sequences located near SOX6 transcriptional start site.[5]

Sox6 appears to have a crucial role in the transcriptional regulation of globin genes, and in directing the terminal differentiation of red blood cells.[6]

See also[edit]


  1. ^ Cohen-Barak O, Hagiwara N, Arlt MF, Horton JP, Brilliant MH (Mar 2001). "Cloning, characterization and chromosome mapping of the human SOX6 gene". Gene 265 (1–2): 157–64. doi:10.1016/S0378-1119(01)00346-8. PMID 11255018. 
  2. ^ a b "Entrez Gene: SOX6 SRY (sex determining region Y)-box 6". 
  3. ^ Murakami A, Ishida S, Thurlow J, Revest JM, Dickson C (August 2001). "SOX6 binds CtBP2 to repress transcription from the Fgf-3 promoter". Nucleic Acids Res. 29 (16): 3347–55. doi:10.1093/nar/29.16.3347. PMC 55854. PMID 11504872. 
  4. ^ Yamashita A, Ito M, Takamatsu N, Shiba T (September 2000). "Characterization of Solt, a novel SoxLZ/Sox6 binding protein expressed in adult mouse testis". FEBS Lett. 481 (2): 147–51. doi:10.1016/S0014-5793(00)01987-6. PMID 10996314. 
  5. ^ Cantu' C, Grande V, Alborelli I, Cassinelli L, Cantu' I, Colzani MT, Ierardi R, Ronzoni L, Cappellini MD, Ferrari G, Ottolenghi S, Ronchi A (September 2010). "A highly conserved SOX6 double binding site mediates SOX6 gene downregulation in erythroid cells". Nucleic Acids Res. 39 (2): 486–501. doi:10.1093/nar/gkq819. PMC 3025548. PMID 20852263. 
  6. ^ Cantù, Claudio; Ierardi, Rossella; Alborelli, Ilaria; Fugazza, Cristina; Cassinelli, Letizia; Piconese, Silvia; Bosè, Francesca; Ottolenghi, Sergio; Ferrari, Giuliana (2011-03-31). "Sox6 enhances erythroid differentiation in human erythroid progenitors". Blood 117 (13): 3669–3679. doi:10.1182/blood-2010-04-282350. ISSN 1528-0020. PMID 21263153. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.