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SPEG complex locus
Protein SPEG PDB 1u2h.png
PDB rendering based on 1u2h.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols SPEG ; APEG-1; APEG1; BPEG; CNM5; SPEGalpha; SPEGbeta
External IDs OMIM615950 HomoloGene55619 IUPHAR: 2203 GeneCards: SPEG Gene
EC number
Species Human Mouse
Entrez 10290 11790
Ensembl ENSG00000072195 ENSMUSG00000026207
UniProt Q15772 Q62407
RefSeq (mRNA) NM_001173476 NM_001085370
RefSeq (protein) NP_001166947 NP_001078839
Location (UCSC) Chr 2:
219.43 – 219.5 Mb
Chr 1:
75.38 – 75.43 Mb
PubMed search [1] [2]

SPEG complex locus, also known as SPEG, is a human gene.[1]

Expression of this gene is thought to serve as a marker for differentiated vascular smooth muscle cells which may have a role in regulating growth and differentiation of this cell type. The encoded protein is highly similar to the corresponding rat and mouse proteins. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of only one variant has been defined.[1]

Mouse Mutant Alleles for Speg
Marker Symbol for Mouse Gene. This symbol is assigned to the genomic locus by the MGI Speg
Mutant Mouse Embryonic Stem Cell Clones. These are the known targeted mutations for this gene in a mouse. Spegtm1a(KOMP)Wtsi
Example structure of targeted conditional mutant allele for this gene
Molecular structure of Speg region with inserted mutation sequence
These Mutant ES Cells can be studied directly or used to generate mice with this gene knocked out. Study of these mice can shed light on the function of Speg:

see Knockout mouse


Further reading[edit]

External links[edit]