SPHK2

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SPHK2
Identifiers
Aliases SPHK2, SK 2, SK-2, SPK 2, SPK-2, sphingosine kinase 2
External IDs MGI: 1861380 HomoloGene: 32456 GeneCards: SPHK2
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001204158
NM_001204159
NM_001204160
NM_001243876
NM_020126

NM_001172561
NM_020011
NM_203280

RefSeq (protein)

NP_001191087
NP_001191088
NP_001191089
NP_001230805
NP_064511

Location (UCSC) Chr 19: 48.62 – 48.63 Mb Chr 7: 45.71 – 45.72 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Sphingosine kinase 2 is a protein that in humans is encoded by the SPHK2 gene.[3]

This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in breast cancer proliferation and chemoresistance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011].[3]

References[edit]

Further reading[edit]