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Aliases SPIB, SPI-B, Spi-B transcription factor
External IDs MGI: 892986 HomoloGene: 79220 GeneCards: 6689
Genetically Related Diseases
Disease Name References
primary biliary cirrhosis
RNA expression pattern
PBB GE SPIB 205861 at tn.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 19: 50.42 – 50.43 Mb Chr 7: 44.53 – 44.53 Mb
PubMed search [2] [3]
View/Edit Human View/Edit Mouse

Transcription factor Spi-B is a protein that in humans is encoded by the SPIB gene.[1][2]


SPI1 (MIM 165170) and SPIB are members of a subfamily of ETS (see ETS1; MIM 164720) transcription factors. ETS proteins share a conserved ETS domain that mediates specific DNA binding. SPIB and SPI1 bind to a purine-rich sequence, the PU box (5-prime-GAGGAA-3-prime).[supplied by OMIM][2]


SPIB has been shown to interact with MAPK3[3] and MAPK8.[3]


  1. ^ Ray D, Bosselut R, Ghysdael J, Mattei MG, Tavitian A, Moreau-Gachelin F (October 1992). "Characterization of Spi-B, a transcription factor related to the putative oncoprotein Spi-1/PU.1". Molecular and Cellular Biology 12 (10): 4297–304. PMC 360353. PMID 1406622. 
  2. ^ a b "Entrez Gene: SPIB Spi-B transcription factor (Spi-1/PU.1 related)". 
  3. ^ a b Mao C, Ray-Gallet D, Tavitian A, Moreau-Gachelin F (February 1996). "Differential phosphorylations of Spi-B and Spi-1 transcription factors". Oncogene 12 (4): 863–73. PMID 8632909. 

Further reading[edit]

  • Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
  • Mao C, Ray-Gallet D, Tavitian A, Moreau-Gachelin F (February 1996). "Differential phosphorylations of Spi-B and Spi-1 transcription factors". Oncogene 12 (4): 863–73. PMID 8632909. 
  • Ray-Gallet D, Tavitian A, Moreau-Gachelin F (June 1996). "An alternatively spliced isoform of the Spi-B transcription factor". Biochemical and Biophysical Research Communications 223 (2): 257–63. doi:10.1006/bbrc.1996.0881. PMID 8670269. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
  • Rao S, Matsumura A, Yoon J, Simon MC (April 1999). "SPI-B activates transcription via a unique proline, serine, and threonine domain and exhibits DNA binding affinity differences from PU.1". The Journal of Biological Chemistry 274 (16): 11115–24. doi:10.1074/jbc.274.16.11115. PMID 10196196. 
  • Nagy M, Chapuis B, Matthes T (February 2002). "Expression of transcription factors Pu.1, Spi-B, Blimp-1, BSAP and oct-2 in normal human plasma cells and in multiple myeloma cells". British Journal of Haematology 116 (2): 429–35. doi:10.1046/j.1365-2141.2002.03271.x. PMID 11841448. 
  • Yamamoto H, Kihara-Negishi F, Yamada T, Suzuki M, Nakano T, Oikawa T (February 2002). "Interaction between the hematopoietic Ets transcription factor Spi-B and the coactivator CREB-binding protein associated with negative cross-talk with c-Myb". Cell Growth & Differentiation 13 (2): 69–75. PMID 11864910. 
  • Schotte R, Rissoan MC, Bendriss-Vermare N, Bridon JM, Duhen T, Weijer K, Brière F, Spits H (February 2003). "The transcription factor Spi-B is expressed in plasmacytoid DC precursors and inhibits T-, B-, and NK-cell development". Blood 101 (3): 1015–23. doi:10.1182/blood-2002-02-0438. PMID 12393575. 
  • Schotte R, Nagasawa M, Weijer K, Spits H, Blom B (December 2004). "The ETS transcription factor Spi-B is required for human plasmacytoid dendritic cell development". The Journal of Experimental Medicine 200 (11): 1503–9. doi:10.1084/jem.20041231. PMC 2211952. PMID 15583020. 
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  • Geng CD, Vedeckis WV (December 2005). "c-Myb and members of the c-Ets family of transcription factors act as molecular switches to mediate opposite steroid regulation of the human glucocorticoid receptor 1A promoter". The Journal of Biological Chemistry 280 (52): 43264–71. doi:10.1074/jbc.M508245200. PMID 16263717. 
  • Dontje W, Schotte R, Cupedo T, Nagasawa M, Scheeren F, Gimeno R, Spits H, Blom B (March 2006). "Delta-like1-induced Notch1 signaling regulates the human plasmacytoid dendritic cell versus T-cell lineage decision through control of GATA-3 and Spi-B". Blood 107 (6): 2446–52. doi:10.1182/blood-2005-05-2090. PMID 16317090. 

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.