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Spi-B transcription factor (Spi-1/PU.1 related)
Symbols SPIB ; SPI-B
External IDs OMIM606802 MGI892986 HomoloGene79220 GeneCards: SPIB Gene
RNA expression pattern
PBB GE SPIB 205861 at tn.png
More reference expression data
Species Human Mouse
Entrez 6689 272382
Ensembl ENSG00000269404 ENSMUSG00000008193
UniProt Q01892 O35906
RefSeq (mRNA) NM_001243998 NM_019866
RefSeq (protein) NP_001230927 NP_063919
Location (UCSC) Chr 19:
50.42 – 50.43 Mb
Chr 7:
44.53 – 44.53 Mb
PubMed search [1] [2]

Transcription factor Spi-B is a protein that in humans is encoded by the SPIB gene.[1][2]

SPI1 (MIM 165170) and SPIB are members of a subfamily of ETS (see ETS1; MIM 164720) transcription factors. ETS proteins share a conserved ETS domain that mediates specific DNA binding. SPIB and SPI1 bind to a purine-rich sequence, the PU box (5-prime-GAGGAA-3-prime).[supplied by OMIM][2]


SPIB has been shown to interact with MAPK3[3] and MAPK8.[3]


  1. ^ Ray D, Bosselut R, Ghysdael J, Mattei MG, Tavitian A, Moreau-Gachelin F (October 1992). "Characterization of Spi-B, a transcription factor related to the putative oncoprotein Spi-1/PU.1". Mol Cell Biol 12 (10): 4297–304. PMC 360353. PMID 1406622. 
  2. ^ a b "Entrez Gene: SPIB Spi-B transcription factor (Spi-1/PU.1 related)". 
  3. ^ a b Mao, C; Ray-Gallet D; Tavitian A; Moreau-Gachelin F (February 1996). "Differential phosphorylations of Spi-B and Spi-1 transcription factors". Oncogene (ENGLAND) 12 (4): 863–73. ISSN 0950-9232. PMID 8632909. 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.