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Serine peptidase inhibitor, Kazal type 1
Protein SPINK1 PDB 1cgi.png
PDB rendering based on 1cgi.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols SPINK1 ; PCTT; PSTI; Spink3; TATI; TCP
External IDs OMIM167790 MGI106202 HomoloGene68300 GeneCards: SPINK1 Gene
RNA expression pattern
PBB GE SPINK1 206239 s at tn.png
More reference expression data
Species Human Mouse
Entrez 6690 20730
Ensembl ENSG00000164266 ENSMUSG00000024503
UniProt P00995 P09036
RefSeq (mRNA) NM_003122 NM_009258
RefSeq (protein) NP_003113 NP_033284
Location (UCSC) Chr 5:
147.82 – 147.83 Mb
Chr 18:
43.73 – 43.74 Mb
PubMed search [1] [2]

Pancreatic secretory trypsin inhibitor (PSTI) also known as serine protease inhibitor Kazal-type 1 (SPINK1) or tumor-associated trypsin inhibitor (TATI) is a protein that in humans is encoded by the SPINK1 gene.[1]

It has been associated with prostate cancer.[2]

See also[edit]


Further reading[edit]

  • Marchbank T, Freeman TC, Playford RJ (1998). "Human pancreatic secretory trypsin inhibitor. Distribution, actions and possible role in mucosal integrity and repair". Digestion 59 (3): 167–74. doi:10.1159/000007485. PMID 9643675. 
  • Pfützer RH, Whitcomb DC (2002). "SPINK1 mutations are associated with multiple phenotypes". Pancreatology 1 (5): 457–60. doi:10.1159/000055847. PMID 12120224. 
  • Schneider A (2005). "Serine protease inhibitor kazal type 1 mutations and pancreatitis". Clin. Lab. Med. 25 (1): 61–78. doi:10.1016/j.cll.2004.12.005. PMID 15749232. 
  • Cohn JA, Mitchell RM, Jowell PS (2005). "The impact of cystic fibrosis and PSTI/SPINK1 gene mutations on susceptibility to chronic pancreatitis". Clin. Lab. Med. 25 (1): 79–100. doi:10.1016/j.cll.2004.12.007. PMID 15749233. 
  • Kandula L, Whitcomb DC, Lowe ME (2006). "Genetic issues in pediatric pancreatitis". Current gastroenterology reports 8 (3): 248–53. doi:10.1007/s11894-006-0083-8. PMID 16764792. 
  • Bartelt DC, Shapanka R, Greene LJ (1977). "The primary structure of the human pancreatic secretory trypsin inhibitor. Amino acid sequence of the reduced S-aminoethylated protein". Arch. Biochem. Biophys. 179 (1): 189–99. doi:10.1016/0003-9861(77)90103-5. PMID 843082. 
  • Hecht HJ, Szardenings M, Collins J, Schomburg D (1992). "Three-dimensional structure of a recombinant variant of human pancreatic secretory trypsin inhibitor (Kazal type)". J. Mol. Biol. 225 (4): 1095–103. doi:10.1016/0022-2836(92)90107-U. PMID 1613792. 
  • Hecht HJ, Szardenings M, Collins J, Schomburg D (1991). "Three-dimensional structure of the complexes between bovine chymotrypsinogen A and two recombinant variants of human pancreatic secretory trypsin inhibitor (Kazal-type)". J. Mol. Biol. 220 (3): 711–22. doi:10.1016/0022-2836(91)90112-J. PMID 1870127. 
  • Freeman TC, Davies R, Calam J (1991). "Interactions of pancreatic secretory trypsin inhibitor in small intestinal juice: its hydrolysis and protection by intraluminal factors". Clin. Chim. Acta 195 (1–2): 27–39. doi:10.1016/0009-8981(90)90191-T. PMID 2093478. 
  • Kido H, Yokogoshi Y, Katunuma N (1990). "A low-molecular-mass Kazal-type protease inhibitor isolated from rat hepatocytes is identical to rat pancreatic secretory trypsin inhibitor II. Purification and amino acid sequence". Eur. J. Biochem. 188 (3): 501–6. doi:10.1111/j.1432-1033.1990.tb15428.x. PMID 2110056. 
  • Tomita N, Horii A, Yamamoto T et al. (1988). "Expression of pancreatic secretory trypsin inhibitor gene in neoplastic tissues". FEBS Lett. 225 (1–2): 113–9. doi:10.1016/0014-5793(87)81141-9. PMID 2961612. 
  • Horii A, Kobayashi T, Tomita N et al. (1988). "Primary structure of human pancreatic secretory trypsin inhibitor (PSTI) gene". Biochem. Biophys. Res. Commun. 149 (2): 635–41. doi:10.1016/0006-291X(87)90415-3. PMID 3501289. 
  • Yamamoto T, Nakamura Y, Nishide J et al. (1985). "Molecular cloning and nucleotide sequence of human pancreatic secretory trypsin inhibitor (PSTI) cDNA". Biochem. Biophys. Res. Commun. 132 (2): 605–12. doi:10.1016/0006-291X(85)91176-3. PMID 3877508. 
  • Huhtala ML, Pesonen K, Kalkkinen N, Stenman UH (1983). "Purification and characterization of a tumor-associated trypsin inhibitor from the urine of a patient with ovarian cancer". J. Biol. Chem. 257 (22): 13713–6. PMID 7142173. 
  • Klaus W, Schomburg D (1993). "Solution structure of a variant of human pancreatic secretory trypsin inhibitor determined by nuclear magnetic resonance spectroscopy". J. Mol. Biol. 229 (3): 695–706. doi:10.1006/jmbi.1993.1073. PMID 8433367. 
  • Chen JM, Mercier B, Audrezet MP, Ferec C (2000). "Mutational analysis of the human pancreatic secretory trypsin inhibitor (PSTI) gene in hereditary and sporadic chronic pancreatitis". J. Med. Genet. 37 (1): 67–9. doi:10.1136/jmg.37.1.67. PMC 1734438. PMID 10691414. 
  • Witt H, Luck W, Hennies HC et al. (2000). "Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis". Nat. Genet. 25 (2): 213–6. doi:10.1038/76088. PMID 10835640. 
  • Pfützer RH, Barmada MM, Brunskill AP et al. (2000). "SPINK1/PSTI polymorphisms act as disease modifiers in familial and idiopathic chronic pancreatitis". Gastroenterology 119 (3): 615–23. doi:10.1053/gast.2000.18017. PMID 10982753. 
  • Kaneko K, Nagasaki Y, Furukawa T et al. (2001). "Analysis of the human pancreatic secretory trypsin inhibitor (PSTI) gene mutations in Japanese patients with chronic pancreatitis". J. Hum. Genet. 46 (5): 293–7. doi:10.1007/s100380170082. PMID 11355022.