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Available structures
PDB Human UniProt search: PDBe RCSB
Aliases SPINK2, HUSI-II, serine peptidase inhibitor, Kazal type 2
External IDs HomoloGene: 77717 GeneCards: SPINK2
Gene location (Human)
Chromosome 4 (human)
Chr. Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for SPINK2
Genomic location for SPINK2
Band No data available Start 56,809,860 bp[1]
End 56,821,742 bp[1]
RNA expression pattern
PBB GE SPINK2 206310 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)


RefSeq (protein)


Location (UCSC) Chr 4: 56.81 – 56.82 Mb n/a
PubMed search [2] n/a
View/Edit Human

Serine protease inhibitor Kazal-type 2 also known as acrosin-trypsin inhibitor is a protein that in humans is encoded by the SPINK2 gene.[3][4]

See also[edit]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000128040 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". 
  3. ^ Moritz A, Grzeschik KH, Wingender E, Fink E (Mar 1993). "Organization and sequence of the gene encoding the human acrosin-trypsin inhibitor (HUSI-II)". Gene. 123 (2): 277–81. PMID 8428671. doi:10.1016/0378-1119(93)90138-S. 
  4. ^ "Entrez Gene: SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)". 


Further reading[edit]

  1. ^ Lee B, Park I, Jin S, Choi H, Kwon JT, Kim J, Jeong J, Cho BN, Eddy EM, Cho C (2011). "Impaired spermatogenesis and fertility in mice carrying a mutation in the Spink2 gene expressed predominantly in testes". J. Biol. Chem. 286: 29108–17. PMC 3190718Freely accessible. PMID 21705336. doi:10.1074/jbc.M111.244905.