This gene encodes an epididymal protease inhibitor, which contains both kunitz-type and WAP-type four-disulfide core (WFDC) protease inhibitor consensus sequences. Most WFDC genes are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene is a member of the WFDC gene family and belongs to the telomeric cluster. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
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Yenugu S, Richardson RT, Sivashanmugam P, et al. (2005). "Antimicrobial activity of human EPPIN, an androgen-regulated, sperm-bound protein with a whey acidic protein motif". Biol. Reprod. 71 (5): 1484–90. doi:10.1095/biolreprod.104.031567. PMID15229136.
Sivashanmugam P, Hall SH, Hamil KG, et al. (2003). "Characterization of mouse Eppin and a gene cluster of similar protease inhibitors on mouse chromosome 2". Gene. 312: 125–34. doi:10.1016/S0378-1119(03)00608-5. PMID12909348.