SPINLW1

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EPPIN
Identifiers
AliasesEPPIN, CT71, CT72, SPINLW1, WAP7, WFDC7, dJ461P17.2, epididymal peptidase inhibitor
External IDsMGI: 2684968 HomoloGene: 128601 GeneCards: EPPIN
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for EPPIN
Genomic location for EPPIN
Band20q13.12Start45,540,626 bp[1]
End45,547,752 bp[1]
RNA expression pattern
PBB GE SPINLW1 206318 at fs.png

PBB GE SPINLW1 206319 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_181502
NM_001302861
NM_020398

NM_001033240
NM_001177848

RefSeq (protein)

NP_001289790
NP_065131
NP_001185915

NP_001028412
NP_001171319

Location (UCSC)Chr 20: 45.54 – 45.55 MbChr 2: 164.58 – 164.59 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Eppin is a protein that in humans is encoded by the SPINLW1 gene.[5][6][7]

This gene encodes an epididymal protease inhibitor, which contains both kunitz-type and WAP-type four-disulfide core (WFDC) protease inhibitor consensus sequences. Most WFDC genes are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene is a member of the WFDC gene family and belongs to the telomeric cluster. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000101448 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000074595 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Richardson RT, Sivashanmugam P, Hall SH, Hamil KG, Moore PA, Ruben SM, French FS, O'Rand M (Jun 2001). "Cloning and sequencing of human Eppin: a novel family of protease inhibitors expressed in the epididymis and testis". Gene. 270 (1–2): 93–102. doi:10.1016/S0378-1119(01)00462-0. PMID 11404006.
  6. ^ Clauss A, Lilja H, Lundwall A (Nov 2002). "A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein". Biochem J. 368 (Pt 1): 233–42. doi:10.1042/BJ20020869. PMC 1222987. PMID 12206714.
  7. ^ a b "Entrez Gene: SPINLW1 serine peptidase inhibitor-like, with Kunitz and WAP domains 1 (eppin)".

Further reading[edit]