SPPL2A

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SPPL2A
Identifiers
Aliases SPPL2A, IMP3, PSL2, signal peptide peptidase like 2A
External IDs MGI: 1913802 HomoloGene: 36411 GeneCards: SPPL2A
RNA expression pattern
PBB GE SPPL2A gnf1h05782 s at fs.png

PBB GE SPPL2A gnf1h00954 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_032802

NM_023220

RefSeq (protein)

NP_116191

NP_075709.2
NP_075709

Location (UCSC) Chr 15: 50.7 – 50.77 Mb Chr 2: 126.89 – 126.93 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Signal peptide peptidase-like 2A, also known as SPPL2A, is a human gene.[3]

Function[edit]

This gene is a member of the signal peptide peptidase-like protease (SPPL) family and encodes an endosomal membrane protein with the conserved active site motifs 'YD' and 'GxGD' in adjacent transmembrane domains (TMDs). This protein plays a role in innate and adaptive immunity by cleaving TNFα in activated dendritic cells.[4][5] A pseudogene of this gene also lies on chromosome 15.[3]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b "Entrez Gene: SPPL2A signal peptide peptidase-like 2A". 
  4. ^ Friedmann E, Hauben E, Maylandt K, et al. (2006). "SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production". Nat. Cell Biol. 8 (8): 843–8. doi:10.1038/ncb1440. PMID 16829952. 
  5. ^ Fluhrer R, Grammer G, Israel L, et al. (2006). "A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b". Nat. Cell Biol. 8 (8): 894–6. doi:10.1038/ncb1450. PMID 16829951. 

Further reading[edit]