SPRY4

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SPRY4
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases SPRY4, HH17, sprouty RTK signaling antagonist 4
External IDs MGI: 1345144 HomoloGene: 8042 GeneCards: SPRY4
Gene location (Human)
Chromosome 5 (human)
Chr. Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for SPRY4
Genomic location for SPRY4
Band n/a Start 142,310,427 bp[1]
End 142,326,455 bp[1]
RNA expression pattern
PBB GE SPRY4 gnf1h07924 at fs.png

PBB GE SPRY4 221489 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001127496
NM_001293289
NM_001293290
NM_030964

NM_011898

RefSeq (protein)

NP_001120968
NP_001280218
NP_001280219
NP_112226

NP_036028

Location (UCSC) Chr 5: 142.31 – 142.33 Mb Chr 5: 38.59 – 38.6 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protein sprouty homolog 4 is a protein that in humans is encoded by the SPRY4 gene.[5][6]

Function[edit]

SPRY4 is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. It is positioned upstream of RAS (see HRAS; MIM 190020) activation and impairs the formation of active GTP-RAS (Leeksma et al., 2002).[supplied by OMIM][6]

See also[edit]

Interactions[edit]

SPRY4 has been shown to interact with TESK1.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000187678 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024427 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Katoh Y, Katoh M (Mar 2006). "FGF signaling inhibitor, SPRY4, is evolutionarily conserved target of WNT signaling pathway in progenitor cells". International Journal of Molecular Medicine. 17 (3): 529–32. PMID 16465403. doi:10.3892/ijmm.17.3.529. 
  6. ^ a b "Entrez Gene: SPRY4 sprouty homolog 4 (Drosophila)". 
  7. ^ Leeksma OC, Van Achterberg TA, Tsumura Y, Toshima J, Eldering E, Kroes WG, Mellink C, Spaargaren M, Mizuno K, Pannekoek H, de Vries CJ (May 2002). "Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase TESK1". European Journal of Biochemistry / FEBS. 269 (10): 2546–56. PMID 12027893. doi:10.1046/j.1432-1033.2002.02921.x. 

Further reading[edit]

  • Zaharieva I, Georgieva L, Nikolov I, Kirov G, Owen MJ, O'Donovan MC, Toncheva D (2008). "Association study in the 5q31-32 linkage region for schizophrenia using pooled DNA genotyping". BMC Psychiatry. 8: 11. PMC 2268687Freely accessible. PMID 18298822. doi:10.1186/1471-244X-8-11. 
  • Cabrita MA, Jäggi F, Widjaja SP, Christofori G (Sep 2006). "A functional interaction between sprouty proteins and caveolin-1". The Journal of Biological Chemistry. 281 (39): 29201–12. PMID 16877379. doi:10.1074/jbc.M603921200. 
  • Wang J, Thompson B, Ren C, Ittmann M, Kwabi-Addo B (May 2006). "Sprouty4, a suppressor of tumor cell motility, is down regulated by DNA methylation in human prostate cancer". The Prostate. 66 (6): 613–24. PMID 16388505. doi:10.1002/pros.20353. 
  • Ding W, Bellusci S, Shi W, Warburton D (Jul 2004). "Genomic structure and promoter characterization of the human Sprouty4 gene, a novel regulator of lung morphogenesis". American Journal of Physiology. Lung Cellular and Molecular Physiology. 287 (1): L52–9. PMID 14977631. doi:10.1152/ajplung.00430.2003. 
  • Sasaki A, Taketomi T, Kato R, Saeki K, Nonami A, Sasaki M, Kuriyama M, Saito N, Shibuya M, Yoshimura A (May 2003). "Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1". Nature Cell Biology. 5 (5): 427–32. PMID 12717443. doi:10.1038/ncb978. 
  • Leeksma OC, Van Achterberg TA, Tsumura Y, Toshima J, Eldering E, Kroes WG, Mellink C, Spaargaren M, Mizuno K, Pannekoek H, de Vries CJ (May 2002). "Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase TESK1". European Journal of Biochemistry / FEBS. 269 (10): 2546–56. PMID 12027893. doi:10.1046/j.1432-1033.2002.02921.x.