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Spectrin, beta, non-erythrocytic 4
Symbols SPTBN4 ; QV; SPNB4; SPTBN3
External IDs OMIM606214 MGI1890574 HomoloGene11879 GeneCards: SPTBN4 Gene
RNA expression pattern
PBB GE SPTBN4 220185 at tn.png
More reference expression data
Species Human Mouse
Entrez 57731 80297
Ensembl ENSG00000160460 ENSMUSG00000011751
UniProt Q9H254 D3YWH8
RefSeq (mRNA) NM_020971 NM_001199234
RefSeq (protein) NP_066022 NP_001186163
Location (UCSC) Chr 19:
40.47 – 40.58 Mb
Chr 7:
27.36 – 27.45 Mb
PubMed search [1] [2]

Spectrin, beta, non-erythrocytic 4, also known as SPTBN4, is a protein that in humans is encoded by the SPTBN4 gene.[1][2]

Spectrin is an actin crosslinking and molecular scaffold protein that links the cell membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. This gene is one member of a family of beta-spectrin genes. The encoded protein localizes to the nuclear matrix, PML nuclear bodies, and cytoplasmic vesicles. A highly similar gene in the mouse is required for localization of specific membrane proteins in polarized regions of neurons. Multiple transcript variants encoding different isoforms have been found for this gene.[1]


SPTBN4 has been shown to interact with PTPRN[2] and DISC1.[3]


  1. ^ a b "Entrez Gene: SPTBN4 spectrin, beta, non-erythrocytic 4". 
  2. ^ a b Berghs S, Aggujaro D, Dirkx R, Maksimova E, Stabach P, Hermel JM, Zhang JP, Philbrick W, Slepnev V, Ort T, Solimena M (November 2000). "betaIV spectrin, a new spectrin localized at axon initial segments and nodes of ranvier in the central and peripheral nervous system". J. Cell Biol. 151 (5): 985–1002. doi:10.1083/jcb.151.5.985. PMC 2174349. PMID 11086001. 
  3. ^ Morris JA, Kandpal G, Ma L, Austin CP (Jul 2003). "DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation". Hum. Mol. Genet. 12 (13): 1591–608. doi:10.1093/hmg/ddg162. PMID 12812986. 

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