From Wikipedia, the free encyclopedia
Jump to: navigation, search
Spectrin, beta, non-erythrocytic 5
External IDs OMIM605916 MGI2685200 HomoloGene41150 GeneCards: SPTBN5 Gene
Species Human Mouse
Entrez 51332 640524
Ensembl ENSG00000137877 ENSMUSG00000074899
UniProt Q9NRC6 A2AP56
RefSeq (mRNA) NM_016642 n/a
RefSeq (protein) NP_057726 n/a
Location (UCSC) Chr 15:
41.85 – 41.89 Mb
Chr 2:
120.05 – 120.09 Mb
PubMed search [1] [2]

Spectrin, beta, non-erythrocytic 5 also known as SPTBN5 is a protein that in humans is encoded by the SPTBN5 gene.[1] SPTBN5 belongs to the spectrin family of cytoskeletal proteins.

Structure and function[edit]

SPTBN5 contains the following domains:[1]

Based on these structural features it is thought that SPTBN5 is likely to form heterodimers and oligomers with alpha-spectrin and to interact directly with cellular membranes.[1]

SPTBN5 is highly expressed in embryoid bodies.[2]


  1. ^ a b c Stabach PR, Morrow JS (July 2000). "Identification and characterization of beta V spectrin, a mammalian ortholog of Drosophila beta H spectrin". J. Biol. Chem. 275 (28): 21385–95. doi:10.1074/jbc.C000159200. PMID 10764729. 
  2. ^ Chaerkady R, Kerr CL, Marimuthu A, Kelkar DS, Kashyap MK, Gucek M, Gearhart JD, Pandey A (January 2009). "Temporal analysis of neural differentiation using quantitative proteomics". J. Proteome Res. 8 (3): 1315–26. doi:10.1021/pr8006667. PMC 2693473. PMID 19173612. 

Further reading[edit]

  • Odell AF, Van Helden DF, Scott JL (2008). "The spectrin cytoskeleton influences the surface expression and activation of human transient receptor potential channel 4 channels". J. Biol. Chem. 283 (7): 4395–407. doi:10.1074/jbc.M709729200. PMID 18048348. 
  • Oguri M, Kato K, Yokoi K, et al. (2010). "Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals". Am. J. Hypertens. 23 (1): 70–7. doi:10.1038/ajh.2009.190. PMID 19851296. 
  • Shoeman RL, Hartig R, Hauses C, Traub P (2002). "Organization of focal adhesion plaques is disrupted by action of the HIV-1 protease". Cell Biol. Int. 26 (6): 529–39. doi:10.1006/cbir.2002.0895. PMID 12119179. 
  • Chardin P, Camonis JH, Gale NW, et al. (1993). "Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2". Science 260 (5112): 1338–43. doi:10.1126/science.8493579. PMID 8493579.