SPhos

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SPhos
SPhos.png
Names
IUPAC name
2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl
Other names
SPhos
Identifiers
657408-07-6 YesY
ChemSpider 9444883 N
Jmol-3D images Image
PubChem 11269872
Properties
C26H35O2P
Molar mass 410.53 g/mol
Appearance colorless solid
Melting point 164 to 166 °C (327 to 331 °F; 437 to 439 K)
organic solvents
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
 N verify (what isYesY/N?)
Infobox references

SPhos is an organophosphorus compound derived from biphenyl. Its palladium complexes exhibit high activity for Suzuki coupling reactions involving aryl chlorides, which are unreactive with palladium complexes of most other phosphine ligands.[1] The ligand has convenient handling characteristics since it is air-stable.[2]

See also[edit]

References[edit]

  1. ^ Barder, T.E.; Walker, S.D.; Martinelli, J.R.; Buchwald, S. L. (2005). "New Catalysts for Suzuki-Miyaura Coupling Processes: Scope and Studies of the Effect of Ligand Structure". J. Am. Chem. Soc. 127 (13): 4685–4696. doi:10.1021/ja042491j. PMID 15796535. 
  2. ^ Altman, R.A.; Buchwald, S.L. (2007). "Pd-Catalyzed Suzuki-Miyaura Reactions of Aryl Halides Using Bulky Biarylmonophosphine Ligands". Nature Protocols 2 (12): 3115–3121. doi:10.1038/nprot.2007.411. PMID 18079711.