Sterol regulatory element-binding protein 2

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Sterol regulatory element binding transcription factor 2
Protein SREBF2 PDB 1ukl.png
PDB rendering based on 1ukl.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols SREBF2 ; SREBP-2; SREBP2; bHLHd2
External IDs OMIM600481 MGI107585 HomoloGene20966 ChEMBL: 1795166 GeneCards: SREBF2 Gene
Species Human Mouse
Entrez 6721 20788
Ensembl ENSG00000198911 ENSMUSG00000022463
UniProt Q12772 Q3U1N2
RefSeq (mRNA) NM_004599 NM_033218
RefSeq (protein) NP_004590 NP_150087
Location (UCSC) Chr 22:
41.83 – 41.91 Mb
Chr 15:
82.15 – 82.21 Mb
PubMed search [1] [2]

Sterol regulatory element-binding protein 2 (SREBP-2) also known as sterol regulatory element binding transcription factor 2 (SREBF2) is a protein that in humans is encoded by the SREBF2 gene.[1]


This gene encodes a ubiquitously expressed transcription factor that controls cholesterol homeostasis by stimulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix leucine zipper (bHLH-Zip) domain.[2] Various single nucleotide polymorphisms (SNPs) of the SREBF2 have been identified and some of them are found to be associated with higher risk of knee osteoarthritis. [3]


SREBF2 has been shown to interact with INSIG1[4][5] and CREB-binding protein.[6]

See also[edit]


  1. ^ Hua X, Yokoyama C, Wu J, Briggs MR, Brown MS, Goldstein JL, Wang X (Dec 1993). "SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element". Proceedings of the National Academy of Sciences of the United States of America 90 (24): 11603–7. doi:10.1073/pnas.90.24.11603. PMC 48032. PMID 7903453. 
  2. ^ "Entrez Gene: SREBF2 sterol regulatory element binding transcription factor 2". 
  3. ^ Qiu XM, Jin CT, Wang W (Apr 2014). "Association between single nucleotide polymorphisms of sterol regulatory element binding protein-2 gene and risk of knee osteoarthritis in a Chinese Han population". The Journal of International Medical Research 42 (2): 320–8. doi:10.1177/0300060513507392. PMID 24496149. 
  4. ^ Dobrosotskaya IY, Goldstein JL, Brown MS, Rawson RB (Sep 2003). "Reconstitution of sterol-regulated endoplasmic reticulum-to-Golgi transport of SREBP-2 in insect cells by co-expression of mammalian SCAP and Insigs". The Journal of Biological Chemistry 278 (37): 35837–43. doi:10.1074/jbc.M306476200. PMID 12842885. 
  5. ^ Yang T, Espenshade PJ, Wright ME, Yabe D, Gong Y, Aebersold R, Goldstein JL, Brown MS (Aug 2002). "Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER". Cell 110 (4): 489–500. doi:10.1016/S0092-8674(02)00872-3. PMID 12202038. 
  6. ^ Oliner JD, Andresen JM, Hansen SK, Zhou S, Tjian R (Nov 1996). "SREBP transcriptional activity is mediated through an interaction with the CREB-binding protein". Genes & Development 10 (22): 2903–11. doi:10.1101/gad.10.22.2903. PMID 8918891. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.