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Aliases SS18L1, CREST, LP2261, nBAF chromatin remodeling complex subunit
External IDs MGI: 2444061 HomoloGene: 9191 GeneCards: SS18L1
RNA expression pattern
PBB GE SS18L1 213140 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 20: 62.14 – 62.18 Mb Chr 2: 180.04 – 180.07 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

SS18-like protein 1 is a protein that in humans is encoded by the SS18L1 gene.[3]


Synovial sarcomas occur most frequently in the extremities around large joints. More than 90% of cases have a recurrent and specific chromosomal translocation, t(X;18)(p11.2;q11.2), in which the 5-prime end of the SS18 gene is fused in-frame to the 3-prime end of the SSX1, SSX2, or SSX4 gene. The SS18L1 gene is homologous to SS18.[3]


SS18L1 has been shown to interact with CREB-binding protein.[4] Biochemical pull down assays reveal SS18L1 to interact with several components of the human SWI/SNF chromatin remodeling complex.[5]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b "Entrez Gene: SS18L1 synovial sarcoma translocation gene on chromosome 18-like 1". 
  4. ^ Aizawa H, Hu SC, Bobb K, Balakrishnan K, Ince G, Gurevich I, Cowan M, Ghosh A (Jan 2004). "Dendrite development regulated by CREST, a calcium-regulated transcriptional activator". Science. United States. 303 (5655): 197–202. doi:10.1126/science.1089845. PMID 14716005. 
  5. ^ Middeljans E, Wan X, Jansen PW, Sharma V, Stunnenberg HG, Logie C (2012). "SS18 together with animal-specific factors defines human BAF-type SWI/SNF complexes.". PLoS ONE. 7 (3): e33834. doi:10.1371/journal.pone.0033834. PMC 3307773Freely accessible. PMID 22442726. 

Further reading[edit]

  • Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811. 
  • de Bruijn DR, Kater-Baats E, Eleveld M, Merkx G, Geurts Van Kessel A (2001). "Mapping and characterization of the mouse and human SS18 genes, two human SS18-like genes and a mouse Ss18 pseudogene.". Cytogenet. Cell Genet. 92 (3-4): 310–9. doi:10.1159/000056920. PMID 11435705. 
  • Storlazzi CT, Mertens F, Mandahl N, Gisselsson D, Isaksson M, Gustafson P, Domanski HA, Panagopoulos I (2003). "A novel fusion gene, SS18L1/SSX1, in synovial sarcoma.". Genes Chromosomes Cancer. 37 (2): 195–200. doi:10.1002/gcc.10210. PMID 12696068. 
  • Aizawa H, Hu SC, Bobb K, Balakrishnan K, Ince G, Gurevich I, Cowan M, Ghosh A (2004). "Dendrite development regulated by CREST, a calcium-regulated transcriptional activator.". Science. 303 (5655): 197–202. doi:10.1126/science.1089845. PMID 14716005. 
  • Pradhan A, Liu Y (2005). "A multifunctional domain of the calcium-responsive transactivator (CREST) that inhibits dendritic growth in cultured neurons.". J. Biol. Chem. 280 (26): 24738–43. doi:10.1074/jbc.M504018200. PMID 15866867. 
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  • de Bruijn DR, Geurts van Kessel A (2006). "Common origin of the human synovial sarcoma associated SS18 and SS18L1 gene loci.". Cytogenet. Genome Res. 112 (3-4): 222–6. doi:10.1159/000089874. PMID 16484776.