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Slingshot protein phosphatase 1
Symbols SSH1 ; SSH1L
External IDs OMIM606778 MGI2686240 HomoloGene41299 GeneCards: SSH1 Gene
EC number,
RNA expression pattern
PBB GE SSH1 221753 at tn.png
More reference expression data
Species Human Mouse
Entrez 54434 231637
Ensembl ENSG00000084112 ENSMUSG00000042121
UniProt Q8WYL5 Q76I79
RefSeq (mRNA) NM_001161330 NM_198109
RefSeq (protein) NP_001154802 NP_932777
Location (UCSC) Chr 12:
108.78 – 108.86 Mb
Chr 5:
113.94 – 113.99 Mb
PubMed search [1] [2]

For the SSH-1 protocol, see Secure Shell#Version 1.x

Protein phosphatase Slingshot homolog 1 is an enzyme that in humans is encoded by the SSH1 gene.[1][2][3]

The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002).[supplied by OMIM][3]


  1. ^ Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O (Apr 2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198. 
  2. ^ Niwa R, Nagata-Ohashi K, Takeichi M, Mizuno K, Uemura T (Feb 2002). "Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin". Cell 108 (2): 233–46. doi:10.1016/S0092-8674(01)00638-9. PMID 11832213. 
  3. ^ a b "Entrez Gene: SSH1 slingshot homolog 1 (Drosophila)". 

Further reading[edit]