SSH1

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SSH1
Identifiers
Aliases SSH1, SSH1L, slingshot protein phosphatase 1
External IDs MGI: 2686240 HomoloGene: 41299 GeneCards: SSH1
Gene location (Human)
Chromosome 12 (human)
Chr. Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for SSH1
Genomic location for SSH1
Band 12q24.11 Start 108,778,192 bp[1]
End 108,857,590 bp[1]
RNA expression pattern
PBB GE SSH1 221753 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001161330
NM_001161331
NM_018984

NM_198109

RefSeq (protein)

NP_001154802
NP_001154803
NP_061857

NP_932777

Location (UCSC) Chr 12: 108.78 – 108.86 Mb Chr 12: 113.94 – 113.99 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

For the SSH-1 protocol, see Secure Shell#Version 1.x

Protein phosphatase Slingshot homolog 1 is an enzyme that in humans is encoded by the SSH1 gene.[5][6][7]

The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002).[supplied by OMIM][7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000084112 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042121 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O (Apr 2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198. 
  6. ^ Niwa R, Nagata-Ohashi K, Takeichi M, Mizuno K, Uemura T (Feb 2002). "Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin". Cell. 108 (2): 233–46. doi:10.1016/S0092-8674(01)00638-9. PMID 11832213. 
  7. ^ a b "Entrez Gene: SSH1 slingshot homolog 1 (Drosophila)". 

Further reading[edit]