SSH2

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SSH2
Protein SSH2 PDB 2nt2.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases SSH2, SSH-2, SSH-2L, slingshot protein phosphatase 2
External IDs MGI: 2679255 HomoloGene: 14116 GeneCards: SSH2
Gene location (Human)
Chromosome 17 (human)
Chr. Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for SSH2
Genomic location for SSH2
Band 17q11.2 Start 29,625,938 bp[1]
End 29,930,276 bp[1]
RNA expression pattern
PBB GE SSH2 gnf1h08347 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001282129
NM_001282130
NM_001282131
NM_033389

NM_001291190
NM_177710

RefSeq (protein)

NP_001269058
NP_001269059
NP_001269060
NP_203747

NP_001278119
NP_808378

Location (UCSC) Chr 17: 29.63 – 29.93 Mb Chr 17: 77.22 – 77.46 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

For the SSH-2 protocol, see Secure Shell#Version 2.x

Protein phosphatase Slingshot homolog 2 is an enzyme that in humans is encoded by the SSH2 gene.[5][6][7]

The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002).[supplied by OMIM][7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000141298 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037926 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Niwa R, Nagata-Ohashi K, Takeichi M, Mizuno K, Uemura T (Feb 2002). "Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin". Cell. 108 (2): 233–46. doi:10.1016/S0092-8674(01)00638-9. PMID 11832213. 
  6. ^ Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O (Feb 2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970. 
  7. ^ a b "Entrez Gene: SSH2 slingshot homolog 2 (Drosophila)". 

Further reading[edit]