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Slingshot protein phosphatase 2
Protein SSH2 PDB 2nt2.png
PDB rendering based on 2nt2.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols SSH2 ; SSH-2; SSH-2L
External IDs OMIM606779 MGI2679255 HomoloGene14116 GeneCards: SSH2 Gene
EC number,
RNA expression pattern
PBB GE SSH2 gnf1h08347 at tn.png
More reference expression data
Species Human Mouse
Entrez 85464 237860
Ensembl ENSG00000141298 ENSMUSG00000037926
UniProt Q76I76 Q5SW75
RefSeq (mRNA) NM_001282129 NM_001291190
RefSeq (protein) NP_001269058 NP_001278119
Location (UCSC) Chr 17:
29.63 – 29.93 Mb
Chr 11:
77.22 – 77.46 Mb
PubMed search [1] [2]

For the SSH-2 protocol, see Secure Shell#Version 2.x

Protein phosphatase Slingshot homolog 2 is an enzyme that in humans is encoded by the SSH2 gene.[1][2][3]

The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002).[supplied by OMIM][3]


  1. ^ Niwa R, Nagata-Ohashi K, Takeichi M, Mizuno K, Uemura T (Feb 2002). "Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin". Cell 108 (2): 233–46. doi:10.1016/S0092-8674(01)00638-9. PMID 11832213. 
  2. ^ Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O (Feb 2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970. 
  3. ^ a b "Entrez Gene: SSH2 slingshot homolog 2 (Drosophila)". 

Further reading[edit]