Protein phosphatase Slingshot homolog 3 is an enzyme that in humans is encoded by the SSH3gene.
The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002).[supplied by OMIM]
^Niwa R, Nagata-Ohashi K, Takeichi M, Mizuno K, Uemura T (Feb 2002). "Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin". Cell108 (2): 233–46. doi:10.1016/S0092-8674(01)00638-9. PMID11832213.
Beausoleil SA, Villén J, Gerber SA et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol.24 (10): 1285–92. doi:10.1038/nbt1240. PMID16964243.CS1 maint: Explicit use of et al. (link)
Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature437 (7062): 1173–8. doi:10.1038/nature04209. PMID16189514.CS1 maint: Explicit use of et al. (link)
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet.36 (1): 40–5. doi:10.1038/ng1285. PMID14702039.CS1 maint: Explicit use of et al. (link)
Ohta Y, Kousaka K, Nagata-Ohashi K et al. (2004). "Differential activities, subcellular distribution and tissue expression patterns of three members of Slingshot family phosphatases that dephosphorylate cofilin.". Genes Cells8 (10): 811–24. doi:10.1046/j.1365-2443.2003.00678.x. PMID14531860.CS1 maint: Explicit use of et al. (link)