SSH3

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SSH3
Identifiers
Aliases SSH3, SSH3L, slingshot protein phosphatase 3
External IDs MGI: 2683546 HomoloGene: 32372 GeneCards: SSH3
Gene location (Human)
Chromosome 11 (human)
Chr. Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for SSH3
Genomic location for SSH3
Band 11q13.2 Start 67,303,448 bp[1]
End 67,312,607 bp[1]
RNA expression pattern
PBB GE SSH3 219241 x at fs.png

PBB GE SSH3 51192 at fs.png

PBB GE SSH3 219919 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_017857
NM_018276

NM_198113
NM_001356620

RefSeq (protein)

NP_060327

NP_932781
NP_001343549

Location (UCSC) Chr 11: 67.3 – 67.31 Mb Chr 11: 4.26 – 4.27 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protein phosphatase Slingshot homolog 3 is an enzyme that in humans is encoded by the SSH3 gene.[5][6]

Function[edit]

The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002).[supplied by OMIM][6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000172830 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034616 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Niwa R, Nagata-Ohashi K, Takeichi M, Mizuno K, Uemura T (January 2002). "Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin". Cell. 108 (2): 233–46. doi:10.1016/S0092-8674(01)00638-9. PMID 11832213. 
  6. ^ a b "Entrez Gene: SSH3 slingshot homolog 3 (Drosophila)". 

Further reading[edit]