From Wikipedia, the free encyclopedia
Jump to: navigation, search
Slingshot protein phosphatase 3
Symbols SSH3 ; SSH3L
External IDs OMIM606780 MGI2683546 HomoloGene32372 GeneCards: SSH3 Gene
EC number,
RNA expression pattern
PBB GE SSH3 219241 x at tn.png
PBB GE SSH3 219919 s at tn.png
PBB GE SSH3 51192 at tn.png
More reference expression data
Species Human Mouse
Entrez 54961 245857
Ensembl ENSG00000172830 ENSMUSG00000034616
UniProt Q8TE77 Q8K330
RefSeq (mRNA) NM_017857 NM_198113
RefSeq (protein) NP_060327 NP_932781
Location (UCSC) Chr 11:
67.3 – 67.31 Mb
Chr 19:
4.26 – 4.27 Mb
PubMed search [1] [2]

Protein phosphatase Slingshot homolog 3 is an enzyme that in humans is encoded by the SSH3 gene.[1][2]

The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002).[supplied by OMIM][2]


  1. ^ Niwa R, Nagata-Ohashi K, Takeichi M, Mizuno K, Uemura T (Feb 2002). "Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin". Cell 108 (2): 233–46. doi:10.1016/S0092-8674(01)00638-9. PMID 11832213. 
  2. ^ a b "Entrez Gene: SSH3 slingshot homolog 3 (Drosophila)". 

Further reading[edit]