SSH3

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SSH3
Identifiers
Aliases SSH3, SSH3L, slingshot protein phosphatase 3
External IDs MGI: 2683546 HomoloGene: 32372 GeneCards: 54961
RNA expression pattern
PBB GE SSH3 219241 x at tn.png

PBB GE SSH3 219919 s at tn.png

PBB GE SSH3 51192 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_017857
NM_018276

NM_198113

RefSeq (protein)

NP_060327.3

NP_932781.1

Location (UCSC) Chr 11: 67.3 – 67.31 Mb Chr 19: 4.26 – 4.27 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Protein phosphatase Slingshot homolog 3 is an enzyme that in humans is encoded by the SSH3 gene.[1][2]

Function[edit]

The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002).[supplied by OMIM][2]

References[edit]

  1. ^ Niwa R, Nagata-Ohashi K, Takeichi M, Mizuno K, Uemura T (January 2002). "Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin". Cell 108 (2): 233–46. doi:10.1016/S0092-8674(01)00638-9. PMID 11832213. 
  2. ^ a b "Entrez Gene: SSH3 slingshot homolog 3 (Drosophila)". 

Further reading[edit]