SSX4 (gene)

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
SSX4
Identifiers
AliasesSSX4, CT5.4, synovial sarcoma, X breakpoint 4, SSX family member 4
External IDsMGI: 2446771 HomoloGene: 133052 GeneCards: SSX4
Gene location (Human)
X chromosome (human)
Chr.X chromosome (human)[1]
X chromosome (human)
Genomic location for SSX4
Genomic location for SSX4
BandXp11.23Start48,383,516 bp[1]
End48,393,347 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_175729
NM_005636

NM_001001450
NM_001134226

RefSeq (protein)

NP_005627
NP_783856
NP_001030004
NP_001035702

n/a

Location (UCSC)Chr X: 48.38 – 48.39 MbChr X: 8.45 – 8.46 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein SSX4 is a protein that in humans is encoded by the SSX4 gene.[5]

The product of this gene belongs to the family of highly homologous synovial sarcoma, X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X;18) chromosomal translocation characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. Chromosome Xp11 contains a segmental duplication resulting in two identical copies of synovial sarcoma, X breakpoint 4, SSX4 and SSX4B, in tail-to-tail orientation. This gene, SSX4, represents the more telomeric copy. Two transcript variants encoding distinct isoforms have been identified for this gene.[5]

References[edit]

Further reading[edit]