ST13

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ST13
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ST13, AAG2, FAM10A1, FAM10A4, HIP, HOP, HSPABP, HSPABP1, P48, PRO0786, SNC6, suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
External IDs MGI: 1917606 HomoloGene: 2921 GeneCards: ST13
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003932
NM_001278589

NM_133726

RefSeq (protein)

NP_001265518
NP_003923

NP_598487.1
NP_598487

Location (UCSC) Chr 22: 40.82 – 40.86 Mb Chr 15: 81.36 – 81.4 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Hsc70-interacting protein also known as suppression of tumorigenicity 13 (ST13) is a protein that in humans is encoded by the ST13 gene.[3][4][5]

Function[edit]

The protein encoded by this gene is an adaptor protein that mediates the association of the heat shock proteins HSP70 and HSP90. This protein has been shown to be involved in the assembly process of glucocorticoid receptor, which requires the assistance of multiple molecular chaperones. The expression of this gene is reported to be downregulated in colorectal carcinoma tissue suggesting that is a candidate tumor suppressor gene.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Zhang Y, Cai X, Schlegelberger B, Zheng S (Mar 1999). "Assignment1 of human putative tumor suppressor genes ST13 (alias SNC6) and ST14 (alias SNC19) to human chromosome bands 22q13 and 11q24→q25 by in situ hybridization". Cytogenet Cell Genet. 83 (1–2): 56–7. doi:10.1159/000015125. PMID 9925927. 
  4. ^ Prapapanich V, Chen S, Nair SC, Rimerman RA, Smith DF (Oct 1996). "Molecular cloning of human p48, a transient component of progesterone receptor complexes and an Hsp70-binding protein". Mol Endocrinol. 10 (4): 420–31. doi:10.1210/me.10.4.420. PMID 8721986. 
  5. ^ a b "Entrez Gene: ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)". 

Further reading[edit]