ST5 (gene)

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ST5
Identifiers
AliasesST5, DENND2B, HTS1, p126, suppression of tumorigenicity 5
External IDsMGI: 108517 HomoloGene: 3951 GeneCards: ST5
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for ST5
Genomic location for ST5
Band11p15.4Start8,693,351 bp[1]
End8,910,951 bp[1]
RNA expression pattern
PBB GE ST5 202440 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005418
NM_139157
NM_213618

NM_001001326
NM_029811

RefSeq (protein)

NP_005409
NP_631896
NP_998783

NP_001001326
NP_084087

Location (UCSC)Chr 11: 8.69 – 8.91 MbChr 7: 109.52 – 109.7 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Suppression of tumorigenicity 5 is a protein that in humans is encoded by the ST5 gene.[5][6] ST5 orthologs [7] have been identified in nearly all mammals for which complete genome data are available.

Function[edit]

This gene was identified by its ability to suppress the tumorigenicity of Hela cells in nude mice. The protein encoded by this gene contains a C-terminal region that shares similarity with the Rab 3 family of small GTP binding proteins. This protein preferentially binds to the SH3 domain of c-Abl kinase, and acts as a regulator of MAPK1/ERK2 kinase, which may contribute to its ability to reduce the tumorigenic phenotype in cells. Three alternatively spliced transcript variants of this gene encoding distinct isoforms are identified.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000166444 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031024 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Lichy JH, Modi WS, Seuanez HN, Howley PM (August 1992). "Identification of a human chromosome 11 gene which is differentially regulated in tumorigenic and nontumorigenic somatic cell hybrids of HeLa cells". Cell Growth & Differentiation. 3 (8): 541–8. PMID 1390339.
  6. ^ a b "Entrez Gene: ST5 suppression of tumorigenicity 5".
  7. ^ "OrthoMaM phylogenetic marker: ST5 coding sequence".

Further reading[edit]