ST8SIA1

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ST8SIA1
Identifiers
Aliases ST8SIA1, GD3S, SIAT8, SIAT8-A, SIAT8A, ST8SiaI, ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
External IDs MGI: 106011 HomoloGene: 2282 GeneCards: ST8SIA1
Genetically Related Diseases
fatty liver disease[1]
RNA expression pattern
PBB GE ST8SIA1 210073 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001304450
NM_003034

NM_011374

RefSeq (protein)

NP_001291379
NP_003025

NP_035504.2
NP_035504

Location (UCSC) Chr 12: 22.06 – 22.44 Mb Chr 6: 142.82 – 142.96 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase is an enzyme that in humans is encoded by the ST8SIA1 gene.[4][5]

Gangliosides are membrane-bound glycosphingolipids containing sialic acid. Ganglioside GD3 is known to be important for cell adhesion and growth of cultured malignant cells. The protein encoded by ST8SIA1 is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to GM3 to produce gangliosides GD3 and GT3. The encoded protein may be found in the Golgi apparatus and is a member of glycosyltransferase family 29.[5]

In melanocytic cells, ST8SIA1 gene expression may be regulated by MITF.[6]

References[edit]

  1. ^ "Diseases that are genetically associated with ST8SIA1 view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ Sasaki K, Watanabe E, Kawashima K, Sekine S, Dohi T, Oshima M, Hanai N, Nishi T, Hasegawa M (Dec 1993). "Expression cloning of a novel Gal beta (1-3/1-4) GlcNAc alpha 2,3-sialyltransferase using lectin resistance selection". J Biol Chem. 268 (30): 22782–7. PMID 7901202. 
  5. ^ a b "Entrez Gene: ST8SIA1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1". 
  6. ^ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. 

Further reading[edit]