ST8SIA4

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ST8SIA4
Identifiers
AliasesST8SIA4, PST, PST1, SIAT8D, ST8SIA-IV, ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
External IDsOMIM: 602547 MGI: 106018 HomoloGene: 4147 GeneCards: ST8SIA4
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for ST8SIA4
Genomic location for ST8SIA4
Band5q21.1Start100,806,933 bp[1]
End100,903,282 bp[1]
RNA expression pattern
PBB GE ST8SIA4 206925 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005668
NM_175052

NM_001159745
NM_009183

RefSeq (protein)

NP_005659
NP_778222

NP_001153217
NP_033209

Location (UCSC)Chr 5: 100.81 – 100.9 MbChr 1: 95.59 – 95.67 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase is an enzyme that in humans is encoded by the ST8SIA4 gene.[5][6]

The protein encoded by this gene catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1). The encoded protein, which is a member of glycosyltransferase family 29, is a type II membrane protein that may be present in the Golgi apparatus. Two transcript variants encoding different isoforms have been found for this gene.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000113532 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040710 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nakayama J, Fukuda MN, Fredette B, Ranscht B, Fukuda M (Aug 1995). "Expression cloning of a human polysialyltransferase that forms the polysialylated neural cell adhesion molecule present in embryonic brain". Proc Natl Acad Sci U S A. 92 (15): 7031–5. doi:10.1073/pnas.92.15.7031. PMC 41465. PMID 7624364.
  6. ^ a b "Entrez Gene: ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4".

Further reading[edit]