This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 15 epidermal growth factor (EGF)-like, and 2 laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein is primarily expressed on sinusoidal endothelial cells of liver, spleen, and lymph node. The receptor has been shown to bind and endocytose ligands such as hyaluronan, low density lipoprotein, Gram-positive and Gram-negative bacteria, and advanced glycosylation end products. Supporting its possible role as a scavenger receptor, the protein has been shown to cycle between the plasma membrane and lysosomes.
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Tamura Y, Adachi H, Osuga J, Ohashi K, Yahagi N, Sekiya M, Okazaki H, Tomita S, Iizuka Y, Shimano H, Nagai R, Kimura S, Tsujimoto M, Ishibashi S (April 2003). "FEEL-1 and FEEL-2 are endocytic receptors for advanced glycation end products". The Journal of Biological Chemistry. 278 (15): 12613–7. doi:10.1074/jbc.M210211200. PMID12473645.
Zhou B, McGary CT, Weigel JA, Saxena A, Weigel PH (May 2003). "Purification and molecular identification of the human hyaluronan receptor for endocytosis". Glycobiology. 13 (5): 339–49. doi:10.1093/glycob/cwg029. PMID12626425.
Harris EN, Weigel JA, Weigel PH (August 2004). "Endocytic function, glycosaminoglycan specificity, and antibody sensitivity of the recombinant human 190-kDa hyaluronan receptor for endocytosis (HARE)". The Journal of Biological Chemistry. 279 (35): 36201–9. doi:10.1074/jbc.M405322200. PMID15208308.
Hansen B, Longati P, Elvevold K, Nedredal GI, Schledzewski K, Olsen R, Falkowski M, Kzhyshkowska J, Carlsson F, Johansson S, Smedsrød B, Goerdt S, Johansson S, McCourt P (February 2005). "Stabilin-1 and stabilin-2 are both directed into the early endocytic pathway in hepatic sinusoidal endothelium via interactions with clathrin/AP-2, independent of ligand binding". Experimental Cell Research. 303 (1): 160–73. doi:10.1016/j.yexcr.2004.09.017. PMID15572036.
Harris EN, Kyosseva SV, Weigel JA, Weigel PH (February 2007). "Expression, processing, and glycosaminoglycan binding activity of the recombinant human 315-kDa hyaluronic acid receptor for endocytosis (HARE)". The Journal of Biological Chemistry. 282 (5): 2785–97. doi:10.1074/jbc.M607787200. PMID17145755.