STAP2

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STAP2
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases STAP2, BKS, signal transducing adaptor family member 2
External IDs MGI: 2147039 HomoloGene: 9798 GeneCards: STAP2
RNA expression pattern
PBB GE STAP2 221610 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001013841
NM_017720

NM_145934

RefSeq (protein)

NP_001013863
NP_060190

NP_666046.1
NP_666046

Location (UCSC) Chr 19: 4.32 – 4.34 Mb Chr 17: 56 – 56.01 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Signal-transducing adaptor protein 2 is a protein that in humans is encoded by the STAP2 gene.[3][4][5]

This gene encodes the substrate of breast tumor kinase, an Src-type non-receptor tyrosine kinase. The encoded protein possesses domains and several tyrosine phosphorylation sites characteristic of adaptor proteins that mediate the interactions linking proteins involved in signal transduction pathways. Alternative splicing results in multiple transcript variants.[5]

Interactions[edit]

STAP2 has been shown to interact with PTK6.[3]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b Mitchell PJ, Sara EA, Crompton MR (Oct 2000). "A novel adaptor-like protein which is a substrate for the non-receptor tyrosine kinase, BRK". Oncogene. 19 (37): 4273–82. doi:10.1038/sj.onc.1203775. PMID 10980601. 
  4. ^ Dehal P, Predki P, Olsen AS, Kobayashi A, Folta P, Lucas S, Land M, Terry A, Ecale Zhou CL, Rash S, Zhang Q, Gordon L, Kim J, Elkin C, Pollard MJ, Richardson P, Rokhsar D, Uberbacher E, Hawkins T, Branscomb E, Stubbs L (Jul 2001). "Human chromosome 19 and related regions in mouse: conservative and lineage-specific evolution". Science. 293 (5527): 104–11. doi:10.1126/science.1060310. PMID 11441184. 
  5. ^ a b "Entrez Gene: STAP2 signal-transducing adaptor protein-2". 

Further reading[edit]