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Available structures
PDB Ortholog search: PDBe RCSB
Aliases STK25, SOK1, YSK1, serine/threonine kinase 25
External IDs MGI: 1891699 HomoloGene: 48428 GeneCards: STK25
RNA expression pattern
PBB GE STK25 201314 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)


RefSeq (protein)


Location (UCSC) Chr 2: 241.49 – 241.51 Mb Chr 1: 93.62 – 93.66 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Serine/threonine-protein kinase 25 is an enzyme that in humans is encoded by the STK25 gene.[3][4][5][6]


STK25 has been shown to interact with STRN,[7] PDCD10[8] and MOBKL3.[7]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Pombo CM, Bonventre JV, Molnar A, Kyriakis J, Force T (Jan 1997). "Activation of a human Ste20-like kinase by oxidant stress defines a novel stress response pathway". EMBO J. 15 (17): 4537–46. PMC 452183Freely accessible. PMID 8887545. 
  4. ^ Osada S, Izawa M, Saito R, Mizuno K, Suzuki A, Hirai S, Ohno S (Jun 1997). "YSK1, a novel mammalian protein kinase structurally related to Ste20 and SPS1, but is not involved in the known MAPK pathways". Oncogene. 14 (17): 2047–57. doi:10.1038/sj.onc.1201043. PMID 9160885. 
  5. ^ Preisinger C, Short B, De Corte V, Bruyneel E, Haas A, Kopajtich R, Gettemans J, Barr FA (Mar 2004). "YSK1 is activated by the Golgi matrix protein GM130 and plays a role in cell migration through its substrate 14-3-3zeta". J Cell Biol. 164 (7): 1009–20. doi:10.1083/jcb.200310061. PMC 2172068Freely accessible. PMID 15037601. 
  6. ^ "Entrez Gene: STK25 serine/threonine kinase 25 (STE20 homolog, yeast)". 
  7. ^ a b Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC (January 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Mol. Cell Proteomics. 8 (1): 157–71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004Freely accessible. PMID 18782753. 
  8. ^ Rual JF, Venkatesan K, Hao T, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 

Further reading[edit]