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STK39

From Wikipedia, the free encyclopedia
STK39
Identifiers
AliasesSTK39, DCHT, PASK, SPAK, serine/threonine kinase 39
External IDsOMIM: 607648; MGI: 1858416; HomoloGene: 22739; GeneCards: STK39; OMA:STK39 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_013233

NM_016866

RefSeq (protein)

NP_037365

NP_058562

Location (UCSC)Chr 2: 167.95 – 168.25 MbChr 2: 68.04 – 68.3 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

STE20/SPS1-related proline-alanine-rich protein kinase is an enzyme that in humans is encoded by the STK39 gene.[5][6]

This gene encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress.[6] Some studies suggest that this gene might be linked to high blood pressure.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000198648Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027030Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Johnston AM, Naselli G, Gonez LJ, Martin RM, Harrison LC, DeAizpurua HJ (Oct 2000). "SPAK, a STE20/SPS1-related kinase that activates the p38 pathway". Oncogene. 19 (37): 4290–7. doi:10.1038/sj.onc.1203784. PMID 10980603.
  6. ^ a b "Entrez Gene: STK39 serine threonine kinase 39 (STE20/SPS1 homolog, yeast)".
  7. ^ "Reuters: Key gene linked to high blood pressure identified". 29 December 2008.

Further reading

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