STS-1 (gene)

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For the 1981 spaceflight see: STS-1

Protein STS-1 PDB 2cpw.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases UBASH3B, STS-1, STS1, TULA-2, p70, TULA2, ubiquitin associated and SH3 domain containing B
External IDs MGI: 1920078 HomoloGene: 13152 GeneCards: UBASH3B
RNA expression pattern
PBB GE STS-1 gnf1h01005 at fs.png

PBB GE STS-1 gnf1h06108 s at fs.png

PBB GE STS-1 gnf1h09784 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 11: 122.66 – 122.81 Mb Chr 9: 41.01 – 41.16 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Ubiquitin-associated and SH3 domain-containing protein B is a protein that in humans is encoded by the UBASH3B gene.[3][4][5]

This gene encodes a protein that contains a ubiquitin associated protein domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. The encoded protein was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor.[5]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Nagase T, Kikuno R, Ohara O (Feb 2002). "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins". DNA Res. 8 (6): 319–27. doi:10.1093/dnares/8.6.319. PMID 11853319. 
  4. ^ Carpino N, Kobayashi R, Zang H, Takahashi Y, Jou ST, Feng J, Nakajima H, Ihle JN (Oct 2002). "Identification, cDNA cloning, and targeted deletion of p70, a novel, ubiquitously expressed SH3 domain-containing protein". Mol Cell Biol. 22 (21): 7491–500. doi:10.1128/MCB.22.21.7491-7500.2002. PMC 135669Freely accessible. PMID 12370296. 
  5. ^ a b "Entrez Gene: STS-1 Cbl-interacting protein Sts-1". 

Further reading[edit]