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Syntaxin 16
Symbols STX16 ; SYN16
External IDs OMIM603666 MGI1923396 HomoloGene2791 GeneCards: STX16 Gene
Species Human Mouse
Entrez 8675 228960
Ensembl ENSG00000124222 ENSMUSG00000027522
UniProt O14662 Q8BVI5
RefSeq (mRNA) NM_001001433 NM_001102423
RefSeq (protein) NP_001001433 NP_001095893
Location (UCSC) Chr 20:
58.65 – 58.68 Mb
Chr 2:
174.08 – 174.1 Mb
PubMed search [1] [2]

Syntaxin-16 is a protein that in humans is encoded by the STX16 gene.[1][2][3][4]

It has been associated with pseudohypoparathyroidism type Ib.[3]


STX16 has been shown to interact with VAMP4.[5]


  1. ^ Tang BL, Low DY, Lee SS, Tan AE, Hong W (Jan 1998). "Molecular cloning and localization of human syntaxin 16, a member of the syntaxin family of SNARE proteins". Biochemical and Biophysical Research Communications 242 (3): 673–9. doi:10.1006/bbrc.1997.8029. PMID 9464276. 
  2. ^ Simonsen A, Bremnes B, Rønning E, Aasland R, Stenmark H (Mar 1998). "Syntaxin-16, a putative Golgi t-SNARE". European Journal of Cell Biology 75 (3): 223–31. doi:10.1016/S0171-9335(98)80116-7. PMID 9587053. 
  3. ^ a b Linglart A, Gensure RC, Olney RC, Jüppner H, Bastepe M (May 2005). "A novel STX16 deletion in autosomal dominant pseudohypoparathyroidism type Ib redefines the boundaries of a cis-acting imprinting control element of GNAS". American Journal of Human Genetics 76 (5): 804–14. doi:10.1086/429932. PMC 1199370. PMID 15800843. 
  4. ^ "Entrez Gene: STX16 syntaxin 16". 
  5. ^ Mallard F, Tang BL, Galli T, Tenza D, Saint-Pol A, Yue X, Antony C, Hong W, Goud B, Johannes L (Feb 2002). "Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform". The Journal of Cell Biology 156 (4): 653–64. doi:10.1083/jcb.200110081. PMC 2174079. PMID 11839770. 

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