STX16

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STX16
Identifiers
AliasesSTX16, SYN16, syntaxin 16
External IDsOMIM: 603666 MGI: 1923396 HomoloGene: 2791 GeneCards: STX16
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for STX16
Genomic location for STX16
Band20q13.32Start58,651,253 bp[1]
End58,679,526 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)

NP_001001433
NP_001128244
NP_001128245
NP_001191797
NP_003754

Location (UCSC)Chr 20: 58.65 – 58.68 MbChr 2: 174.08 – 174.1 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Syntaxin-16 is a protein that in humans is encoded by the STX16 gene.[5][6][7][8]

It has been associated with pseudohypoparathyroidism type Ib. Losing this gene causes loss of methylation at GNAS1 exon A/B.[7]

Interactions[edit]

STX16 has been shown to interact with VAMP4.[9]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000124222 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027522 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Tang BL, Low DY, Lee SS, Tan AE, Hong W (Jan 1998). "Molecular cloning and localization of human syntaxin 16, a member of the syntaxin family of SNARE proteins". Biochemical and Biophysical Research Communications. 242 (3): 673–9. doi:10.1006/bbrc.1997.8029. PMID 9464276.
  6. ^ Simonsen A, Bremnes B, Rønning E, Aasland R, Stenmark H (Mar 1998). "Syntaxin-16, a putative Golgi t-SNARE". European Journal of Cell Biology. 75 (3): 223–31. doi:10.1016/S0171-9335(98)80116-7. PMID 9587053.
  7. ^ a b Linglart A, Gensure RC, Olney RC, Jüppner H, Bastepe M (May 2005). "A novel STX16 deletion in autosomal dominant pseudohypoparathyroidism type Ib redefines the boundaries of a cis-acting imprinting control element of GNAS". American Journal of Human Genetics. 76 (5): 804–14. doi:10.1086/429932. PMC 1199370. PMID 15800843.
  8. ^ "Entrez Gene: STX16 syntaxin 16".
  9. ^ Mallard F, Tang BL, Galli T, Tenza D, Saint-Pol A, Yue X, Antony C, Hong W, Goud B, Johannes L (Feb 2002). "Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform". The Journal of Cell Biology. 156 (4): 653–64. doi:10.1083/jcb.200110081. PMC 2174079. PMID 11839770.

Further reading[edit]