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Syntaxin 5
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols STX5 ; SED5; STX5A
External IDs OMIM603189 MGI1928483 HomoloGene2381 GeneCards: STX5 Gene
RNA expression pattern
PBB GE STX5 203330 s at tn.png
More reference expression data
Species Human Mouse
Entrez 6811 56389
Ensembl ENSG00000162236 ENSMUSG00000010110
UniProt Q13190 Q8K1E0
RefSeq (mRNA) NM_001244666 NM_001167799
RefSeq (protein) NP_001231595 NP_001161271
Location (UCSC) Chr 11:
62.57 – 62.6 Mb
Chr 19:
8.74 – 8.76 Mb
PubMed search [1] [2]

Syntaxin-5 is a protein that in humans is encoded by the STX5 gene.[1][2][3]


STX5 has been shown to interact with NAPA,[4][5] GOSR1,[6][7][8][9] GOSR2,[6][7][8] BET1L[8][10] and USO1.[8][11]


  1. ^ Ravichandran V, Roche PA (July 1997). "Cloning and identification of human syntaxin 5 as a synaptobrevin/VAMP binding protein". J Mol Neurosci 8 (2): 159–61. doi:10.1007/BF02736780. PMID 9188044. 
  2. ^ Parlati F, Varlamov O, Paz K, McNew JA, Hurtado D, Sollner TH, Rothman JE (April 2002). "Distinct SNARE complexes mediating membrane fusion in Golgi transport based on combinatorial specificity". Proc Natl Acad Sci U S A 99 (8): 5424–9. doi:10.1073/pnas.082100899. PMC 122785. PMID 11959998. 
  3. ^ "Entrez Gene: STX5 syntaxin 5". 
  4. ^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  5. ^ Rabouille, C; Kondo H; Newman R; Hui N; Freemont P; Warren G (March 1998). "Syntaxin 5 is a common component of the NSF- and p97-mediated reassembly pathways of Golgi cisternae from mitotic Golgi fragments in vitro". Cell (UNITED STATES) 92 (5): 603–10. doi:10.1016/S0092-8674(00)81128-9. ISSN 0092-8674. PMID 9506515. 
  6. ^ a b Hay, J C; Chao D S; Kuo C S; Scheller R H (April 1997). "Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells". Cell (UNITED STATES) 89 (1): 149–58. doi:10.1016/S0092-8674(00)80191-9. ISSN 0092-8674. PMID 9094723. 
  7. ^ a b Hay, J C; Klumperman J; Oorschot V; Steegmaier M; Kuo C S; Scheller R H (June 1998). "Localization, dynamics, and protein interactions reveal distinct roles for ER and Golgi SNAREs". J. Cell Biol. (UNITED STATES) 141 (7): 1489–502. doi:10.1083/jcb.141.7.1489. ISSN 0021-9525. PMC 2133002. PMID 9647643. 
  8. ^ a b c d Shorter, James; Beard Matthew B, Seemann Joachim, Dirac-Svejstrup A Barbara, Warren Graham (April 2002). "Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115". J. Cell Biol. (United States) 157 (1): 45–62. doi:10.1083/jcb.200112127. ISSN 0021-9525. PMC 2173270. PMID 11927603. 
  9. ^ Subramaniam, V N; Loh E; Hong W (October 1997). "N-Ethylmaleimide-sensitive factor (NSF) and alpha-soluble NSF attachment proteins (SNAP) mediate dissociation of GS28-syntaxin 5 Golgi SNAP receptors (SNARE) complex". J. Biol. Chem. (UNITED STATES) 272 (41): 25441–4. doi:10.1074/jbc.272.41.25441. ISSN 0021-9258. PMID 9325254. 
  10. ^ Xu, Yue; Martin Sally; James David E; Hong Wanjin (October 2002). "GS15 forms a SNARE complex with syntaxin 5, GS28, and Ykt6 and is implicated in traffic in the early cisternae of the Golgi apparatus". Mol. Biol. Cell (United States) 13 (10): 3493–507. doi:10.1091/mbc.E02-01-0004. ISSN 1059-1524. PMC 129961. PMID 12388752. 
  11. ^ Allan, B B; Moyer B D; Balch W E (July 2000). "Rab1 recruitment of p115 into a cis-SNARE complex: programming budding COPII vesicles for fusion". Science (UNITED STATES) 289 (5478): 444–8. doi:10.1126/science.289.5478.444. ISSN 0036-8075. PMID 10903204. 

Further reading[edit]