Bile salt sulfotransferase

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SULT2A1
Protein SULT2A1 PDB 1efh.png
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesSULT2A1, DHEA-ST, DHEAS, HST, ST2, ST2A1, ST2A3, STD, hSTa, sulfotransferase family 2A member 1
External IDsOMIM: 125263 MGI: 3645854 HomoloGene: 37741 GeneCards: SULT2A1
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for SULT2A1
Genomic location for SULT2A1
Band19q13.33Start47,870,467 bp[1]
End47,886,315 bp[1]
RNA expression pattern
PBB GE SULT2A1 206292 s at fs.png

PBB GE SULT2A1 206293 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003167

NM_001101534

RefSeq (protein)

NP_003158

n/a

Location (UCSC)Chr 19: 47.87 – 47.89 MbChr 7: 13.91 – 13.99 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Bile salt sulfotransferase also known as hydroxysteroid sulfotransferase (HST) or sulfotransferase 2A1 (ST2A1) is an enzyme that in humans is encoded by the SULT2A1 gene.[5][6][7]

Function[edit]

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene is primarily expressed in liver and adrenal tissues where the encoded protein sulfonates steroids and bile acids.[5]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000105398 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000074377 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1".
  6. ^ Otterness DM, Wieben ED, Wood TC, Watson WG, Madden BJ, McCormick DJ, Weinshilboum RM (May 1992). "Human liver dehydroepiandrosterone sulfotransferase: molecular cloning and expression of cDNA". Mol. Pharmacol. 41 (5): 865–72. PMID 1588921.
  7. ^ Otterness DM, Mohrenweiser HW, Brandriff BF, Weinshilboum RM (1995). "Dehydroepiandrosterone sulfotransferase gene (STD): localization to human chromosome band 19q13.3". Cytogenet. Cell Genet. 70 (1–2): 45–7. doi:10.1159/000133988. PMID 7736787.

Further reading[edit]

External links[edit]