SUV420H1

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KMT5B
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases KMT5B, CGI85, CGI-85, SUV420H1, lysine methyltransferase 5B
External IDs MGI: 2444557 HomoloGene: 32351 GeneCards: KMT5B
RNA expression pattern
PBB GE SUV420H1 218242 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001300907
NM_001300908
NM_001300909
NM_016028
NM_017635

RefSeq (protein)

NP_001287836
NP_001287837
NP_001287838
NP_057112
NP_060105

Location (UCSC) Chr 11: 68.15 – 68.21 Mb Chr 19: 3.77 – 3.82 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Histone-lysine N-methyltransferase SUV420H1 is an enzyme that in humans is encoded by the SUV420H1 gene.[3][4][5] The enzyme along with WHSC1 is responsible for dimethylation of lysine 20 on histone 4 in mouse and humans.[6][7]

This gene encodes a protein that contains a SET domain. SET domains appear to be protein-protein interaction domains that mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). The function of this gene has not been determined. Two alternatively spliced transcript variants have been found for this gene.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (Aug 2000). "Identification of Novel Human Genes Evolutionarily Conserved in Caenorhabditis elegans by Comparative Proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876Freely accessible. PMID 10810093. 
  4. ^ Twells RC, Metzker ML, Brown SD, Cox R, Garey C, Hammond H, Hey PJ, Levy E, Nakagawa Y, Philips MS, Todd JA, Hess JF (Jun 2001). "The sequence and gene characterization of a 400-kb candidate region for IDDM4 on chromosome 11q13". Genomics. 72 (3): 231–42. doi:10.1006/geno.2000.6492. PMID 11401438. 
  5. ^ a b "Entrez Gene: SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila)". 
  6. ^ Schotta G, Sengupta R, Kubicek S, Malin S, Kauer M, Callén E, Celeste A, Pagani M, Opravil S, De La Rosa-Velazquez IA, Espejo A, Bedford MT, Nussenzweig A, Busslinger M, Jenuwein T (2008). "A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse". Genes Dev. 22: 2048–61. doi:10.1101/gad.476008. PMC 2492754Freely accessible. PMID 18676810. 
  7. ^ Pei H, Zhang L, Luo K, Qin Y, Chesi M, Fei F, Bergsagel PL, Wang L, You Z, Lou Z (2011). "MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites". Nature. 470: 124–8. doi:10.1038/nature09658. PMC 3064261Freely accessible. PMID 21293379. 

Further reading[edit]