SYBL1

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VAMP7
Protein SYBL1 PDB 2dmw.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases VAMP7, SYBL1, TI-VAMP, TIVAMP, VAMP-7, vesicle associated membrane protein 7
External IDs MGI: 1096399 HomoloGene: 4121 GeneCards: VAMP7
RNA expression pattern
PBB GE SYBL1 202829 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001145149
NM_001185183
NM_005638

NM_001302138
NM_011515

RefSeq (protein)

NP_001138621
NP_001172112
NP_005629

NP_001289067.1
NP_035645.1
NP_001289067
NP_035645

Location (UCSC) Chr X: 155.88 – 155.94 Mb n/a
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Vesicle-associated membrane protein 7 (VAMP-7) is a protein that in humans is encoded by the VAMP7 gene.[3][4][5]

Function[edit]

VAMP-7 is a transmembrane protein that is a member of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) family. VAMP-7 localizes to late endosomes and lysosomes and is involved in the fusion of transport vesicles to their target membranes.[5]

Interactions[edit]

SYBL1 has been shown to interact with SNAP23[6][7] and AP3D1.[6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ D'Esposito M, Ciccodicola A, Gianfrancesco F, Esposito T, Flagiello L, Mazzarella R, Schlessinger D, D'Urso M (Jul 1996). "A synaptobrevin-like gene in the Xq28 pseudoautosomal region undergoes X inactivation". Nat. Genet. 13 (2): 227–9. doi:10.1038/ng0696-227. PMID 8640232. 
  4. ^ Filippini F, Rossi V, Galli T, Budillon A, D'Urso M, D'Esposito M (Jul 2001). "Longins: a new evolutionary conserved VAMP family sharing a novel SNARE domain". Trends Biochem. Sci. 26 (7): 407–9. doi:10.1016/S0968-0004(01)01861-8. PMID 11440841. 
  5. ^ a b "Entrez Gene: SYBL1 synaptobrevin-like 1". 
  6. ^ a b Martinez-Arca S, Rudge R, Vacca M, Raposo G, Camonis J, Proux-Gillardeaux V, Daviet L, Formstecher E, Hamburger A, Filippini F, D'Esposito M, Galli T (Jul 2003). "A dual mechanism controlling the localization and function of exocytic v-SNAREs". Proc. Natl. Acad. Sci. U.S.A. 100 (15): 9011–6. doi:10.1073/pnas.1431910100. PMC 166429Freely accessible. PMID 12853575. 
  7. ^ Galli T, Zahraoui A, Vaidyanathan VV, Raposo G, Tian JM, Karin M, Niemann H, Louvard D (Jun 1998). "A novel tetanus neurotoxin-insensitive vesicle-associated membrane protein in SNARE complexes of the apical plasma membrane of epithelial cells". Mol. Biol. Cell. 9 (6): 1437–48. doi:10.1091/mbc.9.6.1437. PMC 25366Freely accessible. PMID 9614185. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.