SYN3

From Wikipedia, the free encyclopedia
Jump to: navigation, search
SYN3
Protein SYN3 PDB 2p0a.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases SYN3
External IDs MGI: 1351334 HomoloGene: 68320 GeneCards: 8224
RNA expression pattern
PBB GE SYN3 206322 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001135774
NM_003490
NM_133632
NM_133633

NM_001164495
NM_013722

RefSeq (protein)

NP_003481.3
NP_598344.2

NP_038750.2

Location (UCSC) Chr 22: 32.51 – 33.06 Mb Chr 10: 86.06 – 86.5 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Synapsin-3 is a protein that in humans is encoded by the SYN3 gene.[1][2]

This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. The protein encoded by this gene shares the synapsin family domain model, with domains A, C, and E exhibiting the highest degree of conservation. The protein contains a unique domain J, located between domains C and E. Based on this gene's localization to 22q12.3, a possible schizophrenia susceptibility locus, and the established neurobiological roles of the synapsins, this family member may represent a candidate gene for schizophrenia. The TIMP3 gene is located within an intron of this gene and is transcribed in the opposite direction. Alternative splicing of this gene results in six transcript variants; however, only two variants have been fully described.[2]

References[edit]

  1. ^ Kao HT, Porton B, Czernik AJ, Feng J, Yiu G, Haring M, Benfenati F, Greengard P (May 1998). "A third member of the synapsin gene family". Proc Natl Acad Sci U S A 95 (8): 4667–72. doi:10.1073/pnas.95.8.4667. PMC 22548. PMID 9539796. 
  2. ^ a b "Entrez Gene: SYN3 synapsin III". 

Further reading[edit]