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Protein SYNCRIP PDB 2dgu.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases SYNCRIP, GRY-RBP, GRYRBP, HNRNPQ, HNRPQ1, NSAP1, PP68, hnRNP-Q, synaptotagmin binding cytoplasmic RNA interacting protein
External IDs MGI: 1891690 HomoloGene: 4648 GeneCards: SYNCRIP
RNA expression pattern
PBB GE SYNCRIP 209024 s at fs.png

PBB GE SYNCRIP 217833 at fs.png

PBB GE SYNCRIP 217832 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)


RefSeq (protein)
Location (UCSC) Chr 6: 85.61 – 85.64 Mb Chr 9: 88.45 – 88.48 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Synaptotagmin binding, cytoplasmic RNA interacting protein, also known as Heterogeneous nuclear ribonucleoprotein Q is a protein that in humans is encoded by the SYNCRIP gene.[3][4][5]


SYNCRIP has been shown to interact with ACF,[4][6] APOBEC1,[4] SYT7[7] and SYT9,[7]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Harris CE, Boden RA, Astell CR (January 1999). "A novel heterogeneous nuclear ribonucleoprotein-like protein interacts with NS1 of the minute virus of mice". Journal of Virology. 73 (1): 72–80. PMC 103810Freely accessible. PMID 9847309. 
  4. ^ a b c Lau PP, Chang BH, Chan L (April 2001). "Two-hybrid cloning identifies an RNA-binding protein, GRY-RBP, as a component of apobec-1 editosome". Biochemical and Biophysical Research Communications. 282 (4): 977–83. doi:10.1006/bbrc.2001.4679. PMID 11352648. 
  5. ^ "Entrez Gene: SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein". 
  6. ^ Blanc V, Navaratnam N, Henderson JO, Anant S, Kennedy S, Jarmuz A, Scott J, Davidson NO (March 2001). "Identification of GRY-RBP as an apolipoprotein B RNA-binding protein that interacts with both apobec-1 and apobec-1 complementation factor to modulate C to U editing". The Journal of Biological Chemistry. 276 (13): 10272–83. doi:10.1074/jbc.M006435200. PMID 11134005. 
  7. ^ a b Mizutani A, Fukuda M, Ibata K, Shiraishi Y, Mikoshiba K (March 2000). "SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms". The Journal of Biological Chemistry. 275 (13): 9823–31. doi:10.1074/jbc.275.13.9823. PMID 10734137. 

Further reading[edit]