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AliasesSYT6, sytVI, synaptotagmin 6
External IDsMGI: 1859544 HomoloGene: 10301 GeneCards: SYT6
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for SYT6
Genomic location for SYT6
Band1p13.2Start114,089,291 bp[1]
End114,153,919 bp[1]
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)Chr 1: 114.09 – 114.15 MbChr 3: 103.58 – 103.65 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Synaptotagmin-6 is a protein that in humans is encoded by the SYT6 gene.[5][6]


Synaptotagmins, such as SYT6, share a common domain structure that includes a transmembrane domain and a cytoplasmic region composed of 2 C2 domains. Some synaptotagmins are involved in synaptic membrane fusion, while others have a more general function in endocytosis. For further information on synaptotagmins, see MIM 185605.[supplied by OMIM][6]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000134207 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027849 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Craxton M (September 2001). "Genomic analysis of synaptotagmin genes". Genomics. 77 (1–2): 43–9. doi:10.1006/geno.2001.6619. PMID 11543631.
  6. ^ a b "Entrez Gene: SYT6 synaptotagmin VI".

Further reading[edit]

  • Roggero CM, Tomes CN, De Blas GA, Castillo J, Michaut MA, Fukuda M, Mayorga LS (September 2005). "Protein kinase C-mediated phosphorylation of the two polybasic regions of synaptotagmin VI regulates their function in acrosomal exocytosis". Developmental Biology. 285 (2): 422–35. doi:10.1016/j.ydbio.2005.07.007. PMID 16111671.
  • Michaut M, De Blas G, Tomes CN, Yunes R, Fukuda M, Mayorga LS (July 2001). "Synaptotagmin VI participates in the acrosome reaction of human spermatozoa". Developmental Biology. 235 (2): 521–9. doi:10.1006/dbio.2001.0316. PMID 11437455.
  • Perin MS (October 1996). "Mirror image motifs mediate the interaction of the COOH terminus of multiple synaptotagmins with the neurexins and calmodulin". Biochemistry. 35 (43): 13808–16. doi:10.1021/bi960853x. PMID 8901523.
  • Li C, Ullrich B, Zhang JZ, Anderson RG, Brose N, Südhof TC (June 1995). "Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins". Nature. 375 (6532): 594–9. doi:10.1038/375594a0. PMID 7791877.