Sabeluzole

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Sabeluzole
Sabeluzole structure.png
Clinical data
ATC code
  • none
Legal status
Legal status
  • Unscheduled
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
Formula C22H26FN3O2S
Molar mass 415.524 g/mol
3D model (Jmol)
  (verify)

Sabeluzole (R-58,735) is a nootropic and neuroprotective drug which was originally developed for the treatment of Alzheimer's disease,[1][2] and has subsequently been researched for other applications such as sleep apnoea.[3] It acts primarily as an NMDA antagonist,[4] but other mechanisms of action may also be important.[5][6]

See also[edit]

References[edit]

  1. ^ Clincke GH; Tritsmans L; Idzikowski C; Amery WK; Janssen PA (1988). "The effect of R 58 735 (Sabeluzole) on memory functions in healthy elderly volunteers". Psychopharmacology. 94 (1): 52–7. doi:10.1007/BF00735880. PMID 3126527. 
  2. ^ Mohr E; Nair NP; Sampson M; Murtha S; Belanger G; Pappas B; Mendis T (August 1997). "Treatment of Alzheimer's disease with sabeluzole: functional and structural correlates". Clinical Neuropharmacology. 20 (4): 338–45. doi:10.1097/00002826-199708000-00005. PMID 9260731. 
  3. ^ Hedner J; Grunstein R; Eriksson B; Ejnell H (May 1996). "A double-blind, randomized trial of sabeluzole--a putative glutamate antagonist--in obstructive sleep apnea". Sleep. 19 (4): 287–9. PMID 8776785. 
  4. ^ Van der Valk JB; Vijverberg HP (February 1993). "Chronic sabeluzole treatment of cultured rat cerebellar granule cells reduces N-methyl-D-aspartate-induced inward current". European Journal of Pharmacology. 232 (1): 131–4. doi:10.1016/0014-2999(93)90738-4. PMID 8458392. 
  5. ^ Geerts H; Nuydens R; De Jong M; Cornelissen F; Nuyens R; Wouters L (1996). "Sabeluzole stabilizes the neuronal cytoskeleton". Neurobiology of Aging. 17 (4): 573–81. doi:10.1016/0197-4580(96)00067-x. PMID 8832632. 
  6. ^ Uberti D; Rizzini C; Galli P; Pizzi M; Grilli M; Lesage A; Spano P; Memo M (June 1997). "Priming of cultured neurons with sabeluzole results in long-lasting inhibition of neurotoxin-induced tau expression and cell death". Synapse (New York, N.Y.). 26 (2): 95–103. doi:10.1002/(SICI)1098-2396(199706)26:2<95::AID-SYN1>3.0.CO;2-8. PMID 9131769.