Saffold virus

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Saffold virus
Virus classification
Group: Group IV ((+)ssRNA)
Order: Picornavirales
Family: Picornaviridae
Genus: Cardiovirus
Species: Cardiovirus B

Saffold virus

Saffold virus (SAFV) is a single-stranded RNA human virus belonging to the Picornaviridae family. Discovered in 2007, it is the first human virus in the Cardiovirus genus and may provide a link to the development of multiple sclerosis or other serious diseases in humans.[1]


SAFV was discovered by Morris S. Jones in 2007 while working at the David Grant USAF Medical Center in the United States.[2] The virus was isolated from a stool sample taken in November 1981 from an 8-month-old female with fever of unknown origin.

This is the first human virus in the Cardiovirus family. Found to occur in high prevalence (>90%) among humans, by analogy SAFV may have effects similar to those observed in mouse TMEV-induced encephalomyelitis, in terms of catalyzing the development of human Multiple Sclerosis or other serious diseases because of infection early in life.[1] Much more study will be needed.


Nine strains of SAFV have been identified; these are named SAFV-1 through to SAFV-9.

See also[edit]


  1. ^ a b Kirkegaard, Karla; Zoll, Jan; Erkens Hulshof, Sandra; Lanke, Kjerstin; Verduyn Lunel, Frans; Melchers, Willem J. G.; Schoondermark-Van De Ven, Esther; Roivainen, Merja; Galama, Jochem M. D. (2009). Kirkegaard, Karla, ed. "Saffold Virus, a Human Theiler's-Like Cardiovirus, is Ubiquitous and Causes Infection Early in Life". PLoS Pathogens. 5 (5): e1000416. PMC 2670511Freely accessible. PMID 19412527. doi:10.1371/journal.ppat.1000416. 
  2. ^ Jones, MS.; Lukashov, VV; Ganac, RD; Schnurr, DP. (July 2007). "Discovery of a novel Human Picornavirus in a stool sample from a pediatric patient presenting with fever of unknown origin". Journal of Clinical Microbiology. 45 (7): 2144–50. PMC 1933019Freely accessible. PMID 17460053. doi:10.1128/JCM.00174-07.