This article needs additional citations for verification. (November 2012) (Learn how and when to remove this template message)
|Group:||Group IV ((+)ssRNA)|
Saffold virus (SAFV) is a single-stranded RNA human virus belonging to the Picornaviridae family. Discovered in 2007, it is the first human virus in the Cardiovirus genus and may provide a link to the development of multiple sclerosis or other serious diseases in humans.
SAFV was discovered by Morris S. Jones in 2007 while working at the David Grant USAF Medical Center in the United States. The virus was isolated from a stool sample taken in November 1981 from an 8-month-old female with fever of unknown origin.
This is the first human virus in the Cardiovirus family. Found to occur in high prevalence (>90%) among humans, by analogy SAFV may have effects similar to those observed in mouse TMEV-induced encephalomyelitis, in terms of catalyzing the development of human Multiple Sclerosis or other serious diseases because of infection early in life. Much more study will be needed.
Nine strains of SAFV have been identified; these are named SAFV-1 through to SAFV-9.
- Kirkegaard, Karla; Zoll, Jan; Erkens Hulshof, Sandra; Lanke, Kjerstin; Verduyn Lunel, Frans; Melchers, Willem J. G.; Schoondermark-Van De Ven, Esther; Roivainen, Merja; Galama, Jochem M. D. (2009). Kirkegaard, Karla, ed. "Saffold Virus, a Human Theiler's-Like Cardiovirus, is Ubiquitous and Causes Infection Early in Life". PLoS Pathogens. 5 (5): e1000416. PMC . PMID 19412527. doi:10.1371/journal.ppat.1000416.
- Jones, MS.; Lukashov, VV; Ganac, RD; Schnurr, DP. (July 2007). "Discovery of a novel Human Picornavirus in a stool sample from a pediatric patient presenting with fever of unknown origin". Journal of Clinical Microbiology. 45 (7): 2144–50. PMC . PMID 17460053. doi:10.1128/JCM.00174-07.